{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-4782-3p has emerged as an important regulator in multiple pathological conditions. In the context of non‐small cell lung cancer (NSCLC), studies aimed at identifying miRNAs targeting the deubiquitinating enzyme USP14—which when overexpressed is linked to tumor cell proliferation and a favorable prognosis—suggest that miR-4782-3p may play a role in modulating USP14 expression, thereby influencing NSCLC pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), miR-4782-3p is expressed at low levels in tumor tissues, a finding that correlates with shorter patient survival. Functional studies revealed that reduced miR-4782-3p levels facilitate HCC cell growth and impede apoptosis, in part by diminishing its targeting of USP14. These results underscore a tumor-suppressive role for miR-4782-3p, with its downregulation contributing to cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in the setting of gestational diabetes mellitus (GDM), a distinct molecular axis involving a circular RNA (hsa_circ_0042260) and miR-4782-3p has been identified. Here, hsa_circ_0042260 is upregulated and appears to act as a molecular sponge for miR-4782-3p, resulting in decreased miR-4782-3p levels. This, in turn, leads to increased expression of LAPTM4A, a downstream target implicated in promoting apoptosis and inflammation in high glucose-stimulated renal cells. Modulation of this axis significantly affects cell viability, suggesting that miR-4782-3p is integral to the regulation of GDM progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ning Wu, Chaoxiong Zhang, Chong Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4782-3p inhibited non-small cell lung cancer growth via USP14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000358626"}], "href": "https://doi.org/10.1159/000358626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24556800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24556800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wentao Bo, Yong Hu, Xielin Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4568"}], "href": "https://doi.org/10.3892/or.2016.4568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26782643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26782643"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rui Ji, Hong Yang, Jiamei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in gestational diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "APMIS (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/apm.13407"}], "href": "https://doi.org/10.1111/apm.13407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38588560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38588560"}]}]}]}