MIR4784 Gene

HGNC Family Non-coding RNAs
Name microRNA 4784
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-4784 emerges as a critical regulatory microRNA in tumor biology, acting primarily by restraining oncogenic pathways that promote cancer cell proliferation, migration, and epithelial‐mesenchymal transition. In cervical cancer, miR-4784 is targeted by the long noncoding RNA LINC01133, which functions as a competing endogenous RNA (ceRNA); by sequestering miR-4784, LINC01133 relieves its inhibitory effect on AHDC1, thereby augmenting AHDC1 expression and contributing to increased tumor growth, invasiveness, and EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in ovarian cancer, the lncRNA LBX2-AS1—activated by the transcription factor ELK1—binds and sponges miR-4784, leading to the upregulation of KDM5C. This derepression of KDM5C facilitates enhanced cell proliferation, migration, and stemness, driving tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Feng, Luyun Qu, Xiuli Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01133 promotes the progression of cervical cancer by sponging miR-4784 to up-regulate AHDC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2019.1647058"}], "href": "https://doi.org/10.1080/15384047.2019.1647058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31390932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31390932"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hangzhi Gu, Rongrong Lin, Feiyun Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-020-09921-5"}], "href": "https://doi.org/10.1007/s10735-020-09921-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33099720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33099720"}]}]}]}
NCBI Gene ID 100616378
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Predicted Functions View MIR4784's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4784's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4784's ARCHS4 Predicted Functions.

Functional Associations

MIR4784 has 1,327 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR4784 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4784 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4784 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4784 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4784 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR4784 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4784 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4784 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4784 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.