{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR4789 – a designation that, based on these studies, appears to refer to the multifunctional transmembrane protein Shisa7 (also known as CKAMP59) – is emerging as a key modulator of synaptic transmission by controlling both excitatory and inhibitory receptor function. In the context of glutamatergic signaling, MIR4789 interacts with AMPA-type glutamate receptors (AMPARs), where it fine‐tunes receptor gating by altering deactivation, desensitization, and recovery kinetics, thereby impacting fast synaptic transmission and long‐term synaptic plasticity essential for processes such as contextual fear memory."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role at excitatory synapses, MIR4789 regulates inhibitory neurotransmission by influencing γ-aminobutyric acid type A receptor (GABAAR) function. It modulates receptor trafficking and surface abundance at GABAergic synapses, accelerates channel deactivation kinetics, and enhances the pharmacological efficacy of benzodiazepines. Moreover, MIR4789 is critical for the homeostatic regulation of tonic inhibition mediated by extrasynaptic α5-containing GABAARs, a process that involves its phosphorylation by protein kinase A and contributes to the modulation of neuronal excitability during sleep/wake cycles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paul Farrow, Konstantin Khodosevich, Yechiam Sapir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.09693"}], "href": "https://doi.org/10.7554/eLife.09693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26623514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26623514"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Leanne J M Schmitz, Remco V Klaassen, Marta Ruiperez-Alonso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.24192"}], "href": "https://doi.org/10.7554/eLife.24192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29199957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29199957"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenyan Han, Jun Li, Kenneth A Pelkey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shisa7 is a GABA"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "A"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " receptor auxiliary subunit controlling benzodiazepine actions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aax5719"}], "href": "https://doi.org/10.1126/science.aax5719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31601770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31601770"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kunwei Wu, Wenyan Han, Qingjun Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity- and sleep-dependent regulation of tonic inhibition by Shisa7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.108899"}], "href": "https://doi.org/10.1016/j.celrep.2021.108899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33761345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33761345"}]}]}]}