{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma cells, miR-4790-3p plays a crucial role in modulating cell fate by promoting autophagy and inhibiting apoptosis. The study observed that treatment with everolimus combined with Ku0063794 causes a significant reduction in miR-4790-3p, which in turn leads to the upregulation of its target gene, zinc finger protein 225 (ZNF225). Functionally, this decrease in miR-4790-3p diminishes autophagic processes while enhancing apoptotic cell death – an effect that contributes to overcoming resistance to everolimus. Moreover, analysis of HCC tissues revealed higher baseline levels of miR-4790-3p paired with reduced ZNF225 expression and increased autophagy, underscoring the importance of this miRNA in promoting a cellular environment favorable to cancer cell survival. Together, these findings suggest that targeting the miR-4790-3p/ZNF225 axis could be a promising strategy to potentiate the anticancer efficacy of mTOR inhibitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ho Joong Choi, Jung Hyun Park, Ok-Hee Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combining Everolimus and Ku0063794 Promotes Apoptosis of Hepatocellular Carcinoma Cells via Reduced Autophagy Resulting from Diminished Expression of miR-4790-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22062859"}], "href": "https://doi.org/10.3390/ijms22062859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33799789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33799789"}]}]}]}