{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-4796 is a microRNA that plays a critical regulatory role in the DNA damage response (DDR) and DNA repair (DR) processes, particularly in the context of radiation exposure in breast cancer cells. This study evaluated the functional impact of miR-4796 by investigating how it modulates the expression of key target genes involved in post‐transcriptional regulation and, consequently, influences the cellular capacity to respond to DNA damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn breast cancer cells, miR-4796 was shown to adjust the cellular sensitivity to radiation by altering the expression levels of genes implicated in DDR, thereby affecting the efficiency of DNA repair mechanisms. These findings suggest that by fine-tuning the expression of its target genes, miR-4796 significantly impacts the cellular response to radiation-induced damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nThe mechanistic insights provided by the study highlight the potential of miR-4796 as a therapeutic target. By modulating DDR and DR pathways, miR-4796 may be exploited to enhance the radiosensitivity of breast cancer cells, thereby improving the effectiveness of radiation therapy in cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ting Jiang, Jinfeng Chen, Zhenzhen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4796 enhances the sensitivity of breast cancer cells to ionising radiation by impairing the DNA repair pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12282-023-01482-1"}], "href": "https://doi.org/10.1007/s12282-023-01482-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37460775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37460775"}]}]}]}