{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR483 – which gives rise to two mature species, miR‐483‐3p and miR‐483‐5p, and is encoded in an intron of the IGF2 gene – plays multifaceted roles in cancer biology. In some settings its expression suppresses metastasis, as shown in colorectal cancer liver colonization (e.g"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", whereas in other tumor types its overexpression promotes oncogenic processes. For example, elevated miR‐483‐3p levels have been observed in Wilms’ tumors and various carcinomas where the microRNA exerts antiapoptotic functions and forms a positive regulatory loop with IGF2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In pancreatic cancer the miR is up‐regulated to drive cell proliferation by targeting tumor suppressors such as DPC4"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and similar oncogenic functions have been documented in tongue and oral squamous cell carcinomas."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, MIR483 has been implicated in therapy resistance, as its altered levels modulate sensitivity to agents such as cisplatin in squamous cell models"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and mediate radio‐resistance in nasopharyngeal carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its dysregulated expression is also emerging as a noninvasive diagnostic or prognostic biomarker in several cancers—including colorectal"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", multiple myeloma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", gastric"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and even in the context of cancer stem cell biology in gastric carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Furthermore, studies in adrenocortical, thyroid, pancreatic, and prostate malignancies"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "20"}]}, {"type": "t", "text": "underscore a context‐dependent impact of MIR483 on tumor cell survival, epithelial–mesenchymal transition, and drug responsiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Finally, in colorectal cancer the co-upregulation of MIR483 with IGF2 contributes to oncogenesis by repressing tumor suppressors like DLC-1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and its circulating levels offer diagnostic promise in several malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "23"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_fs", "start_ref": "3", "end_ref": "5"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "24"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_fs", "start_ref": "14", "end_ref": "17"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_fs", "start_ref": "18", "end_ref": "20"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in neoplasia, MIR483 modulates multiple physiological and pathological processes by targeting key regulatory proteins in diverse tissues. In metabolic regulation, miR‐483‐3p is upregulated in adipose tissue under conditions of early-life nutritional stress, thereby influencing adipocyte differentiation and lipid storage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": " In the nervous system, miR‐483‐5p regulates neural development by downregulating MeCP2 and decreasing aberrant TAU phosphorylation, suggesting potential neuroprotective effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " In vascular contexts, its AT1 receptor–dependent modulation in vascular smooth muscle cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "and its inhibition of angiogenesis via targeting serum response factor in endothelial cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": "indicate a role in cardiovascular homeostasis. Additionally, decreased miR‐483‐5p expression in cumulus cells of polycystic ovary syndrome patients correlates with impaired insulin sensitivity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": ", while in the context of disturbed hemodynamic flow its reduced levels in aortic valve endothelium promote proinflammatory and pro‐calcific signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": " Its functions extend to the regulation of osteoclast formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "32"}]}, {"type": "t", "text": ", the modulation of pulmonary arterial hypertension"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "33"}]}, {"type": "t", "text": ", and the maintenance of extracellular matrix homeostasis in trabecular meshwork cells under oxidative stress"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": "as well as cholesterol homeostasis via PCSK9 suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "35"}]}, {"type": "t", "text": " Finally, by inhibiting chondrogenesis through suppression of SMAD4"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "36"}]}, {"type": "t", "text": "and by promoting synoviocyte proliferation in rheumatoid arthritis via targeting IGF-1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "37"}]}, {"type": "t", "text": ", MIR483 emerges as an important regulator of cellular differentiation and inflammatory responses. Complementary plasma biomarker studies have also underscored its diagnostic potential in Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "38"}]}, {"type": "t", "text": "."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}, {"type": "fg_f", "ref": "38"}, {"type": "fg_f", "ref": "26"}, {"type": "fg_f", "ref": "28"}, {"type": "fg_f", "ref": "39"}, {"type": "fg_fs", "start_ref": "29", "end_ref": "33"}, {"type": "fg_f", "ref": "40"}, {"type": "fg_f", "ref": "34"}, {"type": "fg_f", "ref": "27"}, {"type": "fg_f", "ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jia Min Loo, Alexis Scherl, Alexander Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular metabolic energetics can promote cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.12.018"}], "href": "https://doi.org/10.1016/j.cell.2014.12.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25601461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25601461"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angelo Veronese, Laura Lupini, Jessica Consiglio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic role of miR-483-3p at the IGF2/483 locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-4456"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-4456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20388800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20388800"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mingzhu Liu, Anna Roth, Min Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.224170.113"}], "href": "https://doi.org/10.1101/gad.224170.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24298054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24298054"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jun Hao, Shuyu Zhang, Yingqi Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.11.039"}], "href": "https://doi.org/10.1016/j.febslet.2010.11.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21112326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21112326"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Song Fan, Wei-Xiong Chen, Xiao-Bin Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.03.045"}], "href": "https://doi.org/10.1016/j.canlet.2015.03.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25843291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25843291"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Huanxi Xu, Yuqi Yang, Hongmei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miR-483-5p: a novel diagnostic and prognostic biomarker for patients with oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3514-z"}], "href": "https://doi.org/10.1007/s13277-015-3514-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26224475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26224475"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jinnan Yue, Dacheng Lv, Caiyun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0276-2"}], "href": "https://doi.org/10.1038/s41388-018-0276-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29717264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29717264"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yunhong Tian, Miaohong Yan, Jielin Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-5p decreases the radiosensitivity of nasopharyngeal carcinoma cells by targeting DAPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41374-018-0169-6"}], "href": "https://doi.org/10.1038/s41374-018-0169-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30664712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30664712"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hengmi Cui, Yuan Liu, Jingrui Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF2-derived miR-483 mediated oncofunction by suppressing DLC-1 and associated with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10309"}], "href": "https://doi.org/10.18632/oncotarget.10309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27366946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27366946"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaoyan Qu, Min Zhao, Shuang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating microRNA 483-5p as a novel biomarker for diagnosis survival prediction in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0219-x"}], "href": "https://doi.org/10.1007/s12032-014-0219-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25216866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25216866"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jieyao Cheng, Aiming Yang, Shujun Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-19a-3p and miR-483-5p as Novel Diagnostic Biomarkers for the Early Diagnosis of Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.923444"}], "href": "https://doi.org/10.12659/MSM.923444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32487978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32487978"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kai Wu, Longan Ma, Jinxiang Zhu "}, {"type": "b", "children": [{"type": "t", "text": "miR‑483‑5p promotes growth, invasion and self‑renewal of gastric cancer stem cells by Wnt/β‑catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5603"}], "href": "https://doi.org/10.3892/mmr.2016.5603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27511210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27511210"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "O Chabre, R Libé, G Assie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miR-483-5p and miR-195 are predictive of recurrence risk in adrenocortical cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-13-0051"}], "href": "https://doi.org/10.1530/ERC-13-0051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23756429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23756429"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Claire Agosta, Jonathan Laugier, Laurent Guyon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31363"}], "href": "https://doi.org/10.1002/ijc.31363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29516499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29516499"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaoping Zhang, Lin Liu, Xianzhao Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 483-3p targets Pard3 to potentiate TGF-β1-induced cell migration, invasion, and epithelial-mesenchymal transition in anaplastic thyroid cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0447-1"}], "href": "https://doi.org/10.1038/s41388-018-0447-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30171257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30171257"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Laura Lupini, Felice Pepe, Manuela Ferracin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8913"}], "href": "https://doi.org/10.18632/oncotarget.8913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27120784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27120784"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shenglong Li, Ke Zheng, Yi Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NR2F1-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102563"}], "href": "https://doi.org/10.18632/aging.102563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31801112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31801112"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mohammad-Nazir Menbari, Karim Rahimi, Abbas Ahmadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29167"}], "href": "https://doi.org/10.1002/jcp.29167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31508813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31508813"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Zhi-Gang Yang, Xu-Dong Ma, Zhao-Hui He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Braz J Urol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/S1677-5538.IBJU.2016.0595"}], "href": "https://doi.org/10.1590/S1677-5538.IBJU.2016.0595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28727371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28727371"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jiaojiao Ma, Liu Hong, Guanghui Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.10585"}], "href": "https://doi.org/10.1002/cbin.10585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26801660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26801660"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Long Li, Sufang Li, Manyan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early diagnostic value of circulating microRNAs in patients with suspected acute myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28045"}], "href": "https://doi.org/10.1002/jcp.28045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30623425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30623425"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hui Liang, Yisong Xu, Qiang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in human colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1569530"}], "href": "https://doi.org/10.1080/21691401.2019.1569530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30861353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30861353"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Makoto Abue, Misa Yokoyama, Rie Shibuya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2743"}], "href": "https://doi.org/10.3892/ijo.2014.2743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25384963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25384963"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Thomas Bertero, Isabelle Bourget-Ponzio, Alexandre Puissant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.25330"}], "href": "https://doi.org/10.4161/cc.25330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24067364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24067364"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "D Ferland-McCollough, D S Fernandez-Twinn, I G Cannell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2011.183"}], "href": "https://doi.org/10.1038/cdd.2011.183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22223106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22223106"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kihoon Han, Vincenzo Alessandro Gennarino, Yoontae Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.207456.112"}], "href": "https://doi.org/10.1101/gad.207456.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23431031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23431031"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Siranjeevi Nagaraj, Andrew Want, Katarzyna Laskowska-Kaszub, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22073653"}], "href": "https://doi.org/10.3390/ijms22073653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33915734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33915734"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jacqueline R Kemp, Hamiyet Unal, Russell Desnoyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2014.06.008"}], "href": "https://doi.org/10.1016/j.yjmcc.2014.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24976017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24976017"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yu Qiao, Ning Ma, Xidi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-483-5p controls angiogenesis in vitro and targets serum response factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.08.039"}], "href": "https://doi.org/10.1016/j.febslet.2011.08.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21893058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21893058"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Lin Shi, Shan Liu, Wanqiu Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-5p and miR-486-5p are down-regulated in cumulus cells of metaphase II oocytes from women with polycystic ovary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biomed Online (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.rbmo.2015.06.023"}], "href": "https://doi.org/10.1016/j.rbmo.2015.06.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26283014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26283014"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Joan Fernandez Esmerats, Nicolas Villa-Roel, Sandeep Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.118.312233"}], "href": "https://doi.org/10.1161/ATVBAHA.118.312233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30602302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30602302"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Keqian Li, Shenghao Chen, Pingyuan Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-483-5p is involved in the pathogenesis of osteoporosis by promoting osteoclast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2019.101479"}], "href": "https://doi.org/10.1016/j.mcp.2019.101479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31706013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31706013"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jin Zhang, Yangyang He, Xiaosong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-483 amelioration of experimental pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201911303"}], "href": "https://doi.org/10.15252/emmm.201911303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32324970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32324970"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Wencui Shen, Yating Han, Bingqing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-483-3p Inhibits Extracellular Matrix Production by Targeting Smad4 in Human Trabecular Meshwork Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.15-18036"}], "href": "https://doi.org/10.1167/iovs.15-18036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26747772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26747772"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Jianjie Dong, Ming He, Jie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.143812"}], "href": "https://doi.org/10.1172/jci.insight.143812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33119548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33119548"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Britta A Anderson, Audrey McAlinden "}, {"type": "b", "children": [{"type": "t", "text": "miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.23552"}], "href": "https://doi.org/10.1002/jor.23552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28244607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28244607"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "YueJiao Wang, LinXin Hou, XiaoWei Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-3p promotes cell proliferation and suppresses apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by targeting IGF-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2020.110519"}], "href": "https://doi.org/10.1016/j.biopha.2020.110519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32682111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32682111"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J Dębski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15109"}], "href": "https://doi.org/10.18632/oncotarget.15109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28179587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28179587"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Thomas Bertero, Cécile Gastaldi, Isabelle Bourget-Ponzio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-483-3p controls proliferation in wounded epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.10-168401"}], "href": "https://doi.org/10.1096/fj.10-168401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21676945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21676945"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Xin Dai, Wenjing Pang, Yufeng Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered profile of serum microRNAs in pancreatic cancer-associated new-onset diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diabetes (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1753-0407.12313"}], "href": "https://doi.org/10.1111/1753-0407.12313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25991015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25991015"}]}]}]}