MIR484 Gene

HGNC Family Non-coding RNAs
Name microRNA 484
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Similarly, in metastatic renal cell carcinoma, lower tissue miR-484 levels are associated with prolonged time to progression, underscoring its critical role in tuning drug response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse cancer types, miR-484 displays context-dependent functions that affect tumor progression. In hepatocellular carcinoma, miR-484 is sequestered by circADAMTS13, thereby exerting tumor suppressor effects; in colorectal cancer, long noncoding RNAs such as ZFAS1 and pgm5-as1 sponge miR-484, promoting cell proliferation and invasion. In non-small-cell lung cancer, high miR-484 levels drive migration and proliferation via direct repression of Apaf-1, leading to reduced apoptotic signaling. Moreover, in gastric cancer, miR-484 acts as a tumor suppressor by targeting CCL-18 and concomitantly impeding PI3K/AKT signaling, while in breast cancer models, its modulation influences key regulators such as cytidine deaminase and KLF4, thereby affecting both chemoresistance and cancer stem cell-like properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor growth and chemoresistance, miR-484 also contributes to the regulation of cellular homeostasis in non-malignant contexts. In the reproductive system, elevated miR-484 in granulosa cells from patients with diminished ovarian reserve impairs cell viability and promotes apoptosis by directly targeting YAP1 and disrupting mitochondrial function. In endothelial cells, shear stress–dependent regulation of miR-484 processing via nucleolin (modulated by AMPK) influences the expression of vasoprotective factors such as KLF2 and eNOS, thereby impacting vascular homeostasis. Similarly, exosomal miR-484 derived from bone marrow mesenchymal stem cells has been shown to suppress pancreatic cancer cell proliferation and migration by disrupting mitochondrial metabolism through inhibition of the Wnt/MAPK signaling pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrea Vecchione, Barbara Belletti, Francesca Lovat, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/941980"}], "href": "https://doi.org/10.1155/2015/941980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26064968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26064968"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zongxia Zhao, Ting Shuang, Yan Gao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12424"}], "href": "https://doi.org/10.1002/1878-0261.12424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30537115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30537115"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shuping Xie, Quanxing Ge, Xueyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2017.1407895"}], "href": "https://doi.org/10.1080/15384101.2017.1407895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29179614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29179614"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fu-Gui Ye, Chuan-Gui Song, Zhi-Gang Cao, et al. 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Synonyms HSA-MIR-484, MIR-484, MIRN484
NCBI Gene ID 619553
API
Download Associations
Predicted Functions View MIR484's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR484's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR484's ARCHS4 Predicted Functions.

Functional Associations

MIR484 has 1,595 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR484 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR484 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR484 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR484 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR484 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR484 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR484 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR484 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR484 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR484 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR484 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR484 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR484 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR484 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR484 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.