{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐487b, a member of a 14q32 microRNA cluster, is emerging as an important regulator in cancer biology where its dysregulation is frequently observed. In tobacco‐induced lung carcinogenesis, for example, miR‐487b is epigenetically repressed, resulting in the upregulation of targets involved in oncogenic signaling (such as SUZ12, BMI1, WNT5A, MYC, and KRAS), thereby contributing to malignant transformation (a tumor‐suppressive function when active)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several tumor types—including pediatric gliomas, colorectal and colon cancers, hepatocellular carcinoma, and neuroblastoma—miR‐487b is found at reduced levels, and its re‐expression inhibits key malignant behaviors such as proliferation, migration, invasion, and colony formation. In these contexts, miR‐487b exerts tumor‐suppressive effects by directly targeting oncogenes or molecules that mediate aggressive cancer phenotypes (for instance, GRM3, KRAS, LRP6, MYC, and SUZ12), and its expression level can serve as a prognostic marker that improves risk stratification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other settings the function of miR‐487b appears more nuanced. In non–small cell lung cancer models of acquired temozolomide resistance, higher levels of the miR‐487b–5p isoform are associated with enhanced cell proliferation, migration, and chemoresistance—effects that are partly mediated by repression of molecules such as LAMP2. Similarly, in thyroid cancer, miR‐487 (together with miR‐154) can collaboratively modulate RHOA signaling. Notably, studies in osteosarcoma have reported seemingly contradictory roles: one investigation shows that diminished miR‐487b–3p levels correlate with increased metastasis and chemoresistance via targeting ALDH1A3, whereas another indicates that miR‐487b is overexpressed and promotes malignant behaviors through TRAK2 regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis, miR‐487b also participates in non–tumorigenic processes. In endothelial cells, up‐regulation of miR‐487b enhances neovascularization by targeting thrombospondin 1 (THBS1), an endogenous inhibitor of angiogenesis. Moreover, in models of inflammatory injury—such as lipopolysaccharide‐induced microglial activation relevant to spinal cord injury—and in studies probing its involvement in allergic rhinitis via the IL‑33–ST2 axis, miR‐487b demonstrates the capacity to modulate inflammation and cellular responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sichuan Xi, Hong Xu, Jigui Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI61271"}], "href": "https://doi.org/10.1172/JCI61271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23426183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23426183"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Formosa, E K Markert, A M Lena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.451"}], "href": "https://doi.org/10.1038/onc.2013.451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24166498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24166498"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kazuhiro Kitamura, Masahiro Seike, Tetsuya Okano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-134/487b/655 cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-13-0448"}], "href": "https://doi.org/10.1158/1535-7163.MCT-13-0448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24258346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24258346"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Charles-Henry Gattolliat, Gwénaël Le Teuff, Valérie Combaret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.264"}], "href": "https://doi.org/10.1002/cam4.264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24931722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24931722"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Heather Marion Ames, Ming Yuan, Maria Adelita Vizcaíno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA profiling of low-grade glial and glioneuronal tumors shows an independent role for cluster 14q32.31 member miR-487b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2016.177"}], "href": "https://doi.org/10.1038/modpathol.2016.177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27739438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27739438"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tsuyoshi Hata, Yukako Mokutani, Hidekazu Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3813"}], "href": "https://doi.org/10.3892/ijo.2016.3813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28000854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28000854"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "H Yi, L Geng, A Black, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.499"}], "href": "https://doi.org/10.1038/onc.2016.499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28114282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28114282"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xu Chen, Zhi-Feng Lin, Wen-Jin Xi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation-regulated and tumor-suppressive roles of miR-487b in colorectal cancer via targeting MYC, SUZ12, and KRAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2032"}], "href": "https://doi.org/10.1002/cam4.2032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30791232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30791232"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiuping Li, Yuzhen Guo, Xiyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of serum miR-487b in HBV-related hepatocellular carcinoma and its potential mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Dis (Lond) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/23744235.2021.1901981"}], "href": "https://doi.org/10.1080/23744235.2021.1901981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33783293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33783293"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Liang Bao, Lei Lv, Jinping Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-487b-5p Regulates Temozolomide Resistance of Lung Cancer Cells Through LAMP2-Medicated Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2016.3259"}], "href": "https://doi.org/10.1089/dna.2016.3259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27097129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27097129"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiang-da Fan, Yan Luo, Jun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-154-3p and miR-487-3p synergistically modulate RHOA signaling in the carcinogenesis of thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20193158"}], "href": "https://doi.org/10.1042/BSR20193158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31820783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31820783"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fei Wang, Bao-Guo Ye, Jun-Zhi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.22511"}], "href": "https://doi.org/10.1002/jbt.22511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32267991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32267991"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ming Cheng, Ping-Guo Duan, Zhi-Zeng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7814"}], "href": "https://doi.org/10.3892/or.2020.7814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33125503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33125503"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nianping Feng, Zhengfei Wang, Zhuo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2015.02.002"}], "href": "https://doi.org/10.1016/j.neulet.2015.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25660232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25660232"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "H-C Liu, Y Liao, C-Q Liu "}, {"type": "b", "children": [{"type": "t", "text": "miR-487b mitigates allergic rhinitis through inhibition of the IL-33/ST2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201812_16497"}], "href": "https://doi.org/10.26355/eurrev_201812_16497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30556842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30556842"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dake Tong, Yanyin Zhao, Yang Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-487b suppressed inflammation and neuronal apoptosis in spinal cord injury by targeted Ifitm3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Metab Brain Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11011-022-01015-3"}], "href": "https://doi.org/10.1007/s11011-022-01015-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35802304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35802304"}]}]}]}