{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies across a broad spectrum of malignancies have revealed that miR‑497 predominantly functions as a tumor‐suppressive microRNA. Its frequently reduced expression in cancers such as primary peritoneal carcinoma, gastric, breast, colorectal, hepatocellular, and non‑small cell lung cancer is associated with deregulated cell cycle progression, impaired apoptosis, and chemoresistance. Mechanistically, miR‑497 directly targets several key oncogenic drivers—for example, IGF1‐R, BCL2, CCNE1, and eIF4E—thereby reducing tumor cell proliferation, survival, and colony formation. In many cases, restoration of miR‑497 expression re‐sensitizes resistant cells to chemotherapeutics and attenuates malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to curbing tumor cell growth, miR‑497 plays a crucial role in modulating angiogenesis, invasion, and metastasis. Reduced miR‑497 expression correlates with enhanced angiogenic signaling via upregulation of VEGF‐A, increased activation of VEGFR2 and its downstream pathways (PI3K/AKT and Raf/MEK/ERK), and deregulation of other pro‐metastatic factors such as SMURF1 and matrix metalloproteinases. Consequently, forced expression of miR‑497 not only diminishes endothelial cell tube formation and migratory capacity but also suppresses metastatic spread both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA further layer of complexity in miR‑497 regulation arises from its interactions with long non‑coding RNAs and other competing endogenous RNAs, which can sequester miR‑497 and thereby upregulate its oncogenic targets. In colorectal, gastric, and breast cancers, for example, lncRNAs such as SNHG1, LINC00662, HOXC13‑AS, and SNHG16 act as molecular sponges to downregulate miR‑497 (or its closely related isoform miR‑497‑5p), leading to enhanced expression of targets like MACC1, YAP1, PTEN, PDK3, SERPINE1, SMAD7, KSR1, PD-L1, and PIM1. Other studies have highlighted miR‑497’s role in modulating cellular responses under hypoxic conditions (as seen in glioma) and in non‑oncologic settings including bone homeostasis, diabetic nephropathy, and even skin carcinogenesis through effects on epithelial–mesenchymal transition. Overall, these findings not only underscore the multifaceted regulatory networks involving miR‑497 but also illustrate its potential as both an informative biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Richard J Flavin, Paul C Smyth, Alexandros Laios, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2008.135"}], "href": "https://doi.org/10.1038/modpathol.2008.135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18677302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18677302"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Zhu, DanXia Zhu, Shiqiang Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-010-9797-4"}], "href": "https://doi.org/10.1007/s12032-010-9797-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21258880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21258880"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dan Li, Yulan Zhao, Changxing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-10-1800"}], "href": "https://doi.org/10.1158/1078-0432.CCR-10-1800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21350001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21350001"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sanjay Yadav, Ankita Pandey, Aruna Shukla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.235531"}], "href": "https://doi.org/10.1074/jbc.M111.235531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21878650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21878650"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S T Guo, C C Jiang, G P Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.214"}], "href": "https://doi.org/10.1038/onc.2012.214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22710713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22710713"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Luo, Dongxiang Shen, Xiaoning Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 is a potential prognostic marker in human cervical cancer and functions as a tumor suppressor by targeting the insulin-like growth factor 1 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Surgery (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.surg.2012.12.004"}], "href": "https://doi.org/10.1016/j.surg.2012.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23453369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23453369"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Laura Creevey, Jacqueline Ryan, Harry Harvey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-12-23"}], "href": "https://doi.org/10.1186/1476-4598-12-23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23531080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23531080"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mayuko Furuta, Ken-ichi Kozaki, Kousuke Tanimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060155"}], "href": "https://doi.org/10.1371/journal.pone.0060155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23544130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23544130"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wen-yan Zhao, Yan Wang, Zhong-jun An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-497 promotes tumor growth and angiogenesis by targeting HDGF in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.05.010"}], "href": "https://doi.org/10.1016/j.bbrc.2013.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23673296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23673296"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yan-yan Qiu, Qiang Hu, Qing-feng Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-013-1342-6"}], "href": "https://doi.org/10.1007/s13277-013-1342-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24375248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24375248"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yin Xie, Rong-Rong Wei, Guo-Liang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0844-4"}], "href": "https://doi.org/10.1007/s12032-014-0844-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24464213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24464213"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Toshihiko Itesako, Naohiko Seki, Hirofumi Yoshino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0084311"}], "href": "https://doi.org/10.1371/journal.pone.0084311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24520312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24520312"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Weidong Li, Xuejun Jin, Xubin Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.05.011"}], "href": "https://doi.org/10.1016/j.bbrc.2014.05.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24845562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24845562"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wei Wang, Fang Ren, Qinghua Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.05.053"}], "href": "https://doi.org/10.1016/j.bbrc.2014.05.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24858688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24858688"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jin Lan, Yajun Xue, Huairui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced miR-497 decreases glioma cell sensitivity to TMZ by inhibiting apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2014.07.021"}], "href": "https://doi.org/10.1016/j.febslet.2014.07.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25080009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25080009"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jianwei Xu, Tianxiao Wang, Zhe Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2184"}], "href": "https://doi.org/10.18632/oncotarget.2184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25149530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25149530"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wei Wang, Fang Ren, Qinghua Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3439"}], "href": "https://doi.org/10.3892/or.2014.3439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25176450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25176450"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaolei Zhao, Zhenhua Zhao, Wenchao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-497 is associated with poor prognosis in renal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25755771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25755771"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shaohua Xu, Guang-Bo Fu, Zhen Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4762"}], "href": "https://doi.org/10.18632/oncotarget.4762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26238185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26238185"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Katharina Troppan, Kerstin Wenzl, Martin Pichler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms160818077"}], "href": "https://doi.org/10.3390/ijms160818077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26251897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26251897"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Chongbiao Huang, Ruijue Ma, Jie Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-497 Suppresses YAP1 and Inhibits Tumor Growth in Non-Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000430358"}], "href": "https://doi.org/10.1159/000430358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26316081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26316081"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jing-Jun Yan, Yu-Nan Zhang, Jia-Zhi Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5012"}], "href": "https://doi.org/10.18632/oncotarget.5012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26336827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26336827"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yingfeng Tu, Li Liu, Dongliang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep13827"}], "href": "https://doi.org/10.1038/srep13827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26345385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26345385"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Aiqin Gu, Jianhong Lu, Weimin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of miR-497 in VEGF-A-mediated cancer cell growth and invasion in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2015.10.013"}], "href": "https://doi.org/10.1016/j.biocel.2015.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26485685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26485685"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shumin Wang, Yingxi Mo, Kaoru Midorikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5651"}], "href": "https://doi.org/10.18632/oncotarget.5651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26486082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26486082"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yujuan Zhang, Donghong Zhang, Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep17942"}], "href": "https://doi.org/10.1038/srep17942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26656154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26656154"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Lin Wang, Cheng-fei Jiang, Dong-mei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6545"}], "href": "https://doi.org/10.18632/oncotarget.6545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26673620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26673620"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Maria Ines Almeida, Andreia Machado Silva, Daniel Marques Vasconcelos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6589"}], "href": "https://doi.org/10.18632/oncotarget.6589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26683705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26683705"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Zhihao Wu, Xuehong Cai, Chenggang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4529"}], "href": "https://doi.org/10.3892/or.2015.4529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26718330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26718330"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Qianshan Ding, Ke He, Tao Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mt.2016.9"}], "href": "https://doi.org/10.1038/mt.2016.9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26755331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26755331"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yanyan Qiu, Hui Yu, Xiaojing Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12237"}], "href": "https://doi.org/10.1111/cpr.12237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26840372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26840372"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Jingjing Liu, Yang Zhou, Zhendong Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-497 Modulates Breast Cancer Cell Proliferation, Invasion, and Survival by Targeting SMAD7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2016.3282"}], "href": "https://doi.org/10.1089/dna.2016.3282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27303812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27303812"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Lei Ma, Yongjian Zhou, Xiaojun Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13670"}], "href": "https://doi.org/10.18632/oncotarget.13670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27911852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27911852"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "A Mizrahi, A Barzilai, D Gur-Wahnon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.315"}], "href": "https://doi.org/10.1038/onc.2017.315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28925390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28925390"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Samuel G Rouleau, Jean-Michel Garant, François Bolduc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-Quadruplexes influence pri-microRNA processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2017.1405211"}], "href": "https://doi.org/10.1080/15476286.2017.1405211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29171334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29171334"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Zhen Liu, Yangyang Yao, Shanshan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00662 promotes gastric cancer cell growth by modulating the Hippo-YAP1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.09.191"}], "href": "https://doi.org/10.1016/j.bbrc.2018.09.191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30297104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30297104"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Gang Li, Kai Wang, Jiansheng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-497-5p inhibits tumor cell growth and invasion by targeting SOX5 in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28345"}], "href": "https://doi.org/10.1002/jcb.28345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30816573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30816573"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Xiaowei Li, Qiang Wang, Yiqi Rui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXC13-AS promotes breast cancer cell growth through regulating miR-497-5p/PTEN axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28800"}], "href": "https://doi.org/10.1002/jcp.28800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31066051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31066051"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Jinghui Bai, Jian Xu, Jian Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA SNHG1 cooperated with miR-497/miR-195-5p to modify epithelial-mesenchymal transition underlying colorectal cancer exacerbation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29065"}], "href": "https://doi.org/10.1002/jcp.29065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31276207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31276207"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Lan Feng, Kai Cheng, Rongjia Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190654"}], "href": "https://doi.org/10.1042/BSR20190654"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409724"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Qiaojuan Zhu, Yazhao Li, Yang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG16 promotes proliferation and inhibits apoptosis of diffuse large B-cell lymphoma cells by targeting miR-497-5p/PIM1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14601"}], "href": "https://doi.org/10.1111/jcmm.14601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31483572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31483572"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Jianhua Ma, Xiao Lin, Chu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-181c-5p and miR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgz300"}], "href": "https://doi.org/10.1210/clinem/dgz300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31872255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31872255"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Jia Wang, Su-Mei Zhao "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-antisense non-coding RNA in the INK4 locus promotes pyroptosis via miR-497/thioredoxin-interacting protein axis in diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118728"}], "href": "https://doi.org/10.1016/j.lfs.2020.118728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33160992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33160992"}]}]}]}