| Name | mir-497-195 cluster host gene |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study detailed in the abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "describes a long non‐coding RNA expressed from the DNA strand opposite to the ALOX12 gene. Although the request refers to MIR497HG, the abstract provided focuses on ALOX12-AS1—a lncRNA that, much like certain host genes for microRNAs, modulates gene function at the post‐transcriptional level. In this work, ALOX12-AS1 is shown to be ubiquitously expressed in both primary tissues and various cell types, where it localizes in the nucleus, nucleolus, and the cytosol. Under stimulation with phorbol ester, this lncRNA translocates from the nucleus to the cytosol in monocytic THP-1 cells, where its increased cytoplasmic presence correlates with reduced levels of ALOX12 protein despite stable mRNA expression. This observation supports the model that the lncRNA forms an antisense–sense duplex with the ALOX12 mRNA and interacts with ribosomal proteins, thereby downregulating translation. Consequently, this antisense RNA-mediated translational control mechanism provides an additional layer of regulation in the cellular production of bioactive lipid mediators, which are critically involved in healthy physiology and disease pathogenesis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mohammad Golam Sabbir, Carla G Taylor, Peter Zahradka "}, {"type": "b", "children": [{"type": "t", "text": "Antisense overlapping long non-coding RNA regulates coding arachidonate 12-lipoxygenase gene by translational interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Biol Lipids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2021.158987"}], "href": "https://doi.org/10.1016/j.bbalip.2021.158987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34174394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34174394"}]}]}]}
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| Synonyms | MIR195HG |
| NCBI Gene ID | 100506755 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR497HG has 705 functional associations with biological entities spanning 5 categories (molecular profile, organism, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.
Click the + buttons to view associations for MIR497HG from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR497HG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR497HG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with MIR497HG gene from the CellMarker Gene-Cell Type Associations dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR497HG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with MIR497HG gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR497HG gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR497HG gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR497HG gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIR497HG gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MIR497HG gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR497HG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR497HG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR497HG gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR497HG gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
