MIR499A Gene

HGNC Family Non-coding RNAs
Name microRNA 499a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Its release from necrotic myocardium during acute infarction and during coronary bypass procedures has been documented, and elevated serum levels have been correlated not only with myocardial infarction but also with the severity of traumatic brain injury. Such studies underscore the potential utility of MIR499A as a non‐invasive diagnostic tool in cardiovascular and related systemic injuries."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncologic arena, MIR499A exhibits context‐dependent roles that have been explored through investigations of its genetic variants and expression patterns. Several studies have evaluated single nucleotide polymorphisms in pre‐MIR499 (e.g., rs3746444) in a range of cancers including breast, prostate, gastric, and hepatocellular carcinoma, although associations have been variable."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "17"}]}, {"type": "t", "text": " In addition, functional studies have demonstrated that MIR499A can be secreted in exosomes where its up‐regulation promotes cancer cell proliferation, migration, and epithelial–mesenchymal transition via signaling pathways such as mTOR."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " A regulatory axis involving MIR499A has also been delineated in glioma, wherein long non‐coding RNAs modulate its activity to affect downstream effectors like LMX1A and NLRC5, ultimately influencing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthew L Bell, Massimo Buvoli, Leslie A Leinwand "}, {"type": "b", "children": [{"type": "t", "text": "Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01370-09"}], "href": "https://doi.org/10.1128/MCB.01370-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20154144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20154144"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joseph T C Shieh, Yu Huang, Jacqueline Gilmore, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Helicobacter (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1523-5378.2010.00806.x"}], "href": "https://doi.org/10.1111/j.1523-5378.2010.00806.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21073609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21073609"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hong Zhi, Lina Wang, Genshan Ma, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2011.12.026"}], "href": "https://doi.org/10.1016/j.gene.2011.12.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22222140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22222140"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yu Xiang, Song Fan, Ju Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-012-1532-0"}], "href": "https://doi.org/10.1007/s11033-012-1532-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22311030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22311030"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hikmet Akkiz, Süleyman Bayram, Aynur Bekar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22393998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22393998"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mohsen Omrani, Mohammad Hashemi, Ebrahim Eskandari-Nasab, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa-mir-499 rs3746444 gene polymorphism is associated with susceptibility to breast cancer in an Iranian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/bmm.13.118"}], "href": "https://doi.org/10.2217/bmm.13.118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24521023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24521023"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qian Xu, Jing-wei Liu, Yuan Yuan "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutat Res Rev Mutat Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mrrev.2014.09.004"}], "href": "https://doi.org/10.1016/j.mrrev.2014.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25795117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25795117"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "P Qi, L Wang, B Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2015.June.11.2"}], "href": "https://doi.org/10.4238/2015.June.11.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26125831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26125831"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zhiliang Xu, Yeming Han, Jiying Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-499a-5p promotes cell proliferation, migration and EMT via mTOR signaling pathway in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2019.03.035"}], "href": "https://doi.org/10.1016/j.yexcr.2019.03.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30978341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30978341"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zheqi Zong, Yichen Song, Yixue Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR-499a-5p/LMX1A/NLRC5 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14362"}], "href": "https://doi.org/10.1111/jcmm.14362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31207033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31207033"}]}]}]}
Synonyms MIR-499A, HSA-MIR-499A, MIR499, MIRN499
NCBI Gene ID 574501
API
Download Associations
Predicted Functions View MIR499A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR499A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR499A's ARCHS4 Predicted Functions.

Functional Associations

MIR499A has 829 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.

Click the + buttons to view associations for MIR499A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR499A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR499A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR499A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR499A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR499A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR499A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR499A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR499A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with MIR499A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR499A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR499A from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR499A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR499A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR499A gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR499A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR499A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR499A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIR499A gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR499A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR499A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.