MIR499B Gene

HGNC Family Non-coding RNAs
Name microRNA 499b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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These findings suggest that MIR499B may reflect disease severity and could serve as a noninvasive indicator for cardiovascular pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother study focused on cervical cancer found that a specific MIR499B variant—miR-499b-5p—impacts tumorigenesis by directly targeting the Notch1 signaling pathway. This regulation of Notch1 not only underscores the role of MIR499B in cancer development but also highlights its promise as a potential clinical target in cervical malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies further implicate MIR499B in immune and reproductive disorders. Polymorphism analyses have linked the rs3746444 variant of MIR499B to endometriosis, inflammatory arthritis, and a spectrum of autoimmune diseases. These associations point to a broader immunomodulatory function whereby variations in MIR499B may influence disease susceptibility and severity across different clinical contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is noteworthy that while research on posttranscriptional regulatory proteins (such as the Lsm11 factor involved in U7 snRNP assembly for histone mRNA processing) provides insight into RNA metabolism, the distinct functions of MIR499B in gene silencing and disease modulation set it apart as a critical regulatory microRNA in human pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pamela Ajuyah, Meredith Hill, Alireza Ahadi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/9842427"}], "href": "https://doi.org/10.1155/2019/9842427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31885748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31885748"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "H-M Liu, F Ji, Y Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-499b-5p inhibits cervical cancer cell proliferation and induces apoptosis by targeting the Notch1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202110_26992"}], "href": "https://doi.org/10.26355/eurrev_202110_26992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34730202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34730202"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M Farsimadan, M Ismail Haje, C Khudhur Mawlood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA variants in endometriosis and its severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Biomed Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09674845.2021.1889157"}], "href": "https://doi.org/10.1080/09674845.2021.1889157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33583336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33583336"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dingjian Wang, Guixia Pan "}, {"type": "b", "children": [{"type": "t", "text": "Association of rs2910164 Polymorphism in miRNA-146 and rs3746444 Polymorphism in miRNA-499 with Inflammatory Arthritis: A Meta-Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/7305750"}], "href": "https://doi.org/10.1155/2019/7305750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31223622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31223622"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiangjian Kong, Shuling Diao, Huipu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0266265"}], "href": "https://doi.org/10.1371/journal.pone.0266265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35358276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35358276"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ramesh S Pillai, Matthias Grimmler, Gunter Meister, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.274403"}], "href": "https://doi.org/10.1101/gad.274403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12975319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12975319"}]}]}]}
Synonyms MIR499A, HSA-MIR-499B
NCBI Gene ID 100616134
API
Download Associations
Predicted Functions View MIR499B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR499B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR499B's ARCHS4 Predicted Functions.

Functional Associations

MIR499B has 266 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR499B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR499B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR499B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR499B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR499B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR499B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR499B gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR499B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR499B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR499B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.