{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies have revealed that miR‑5000‑3p is upregulated in specific tumor cell subpopulations. In colon cancer, for instance, this microRNA is markedly elevated in the side population of cells—an aggressive subset implicated in multidrug resistance. This upregulation suggests that miR‑5000‑3p may serve as a potential biomarker for identifying drug‐resistant cancer stem-like cells, thereby offering a novel target for overcoming resistance mechanisms in advanced colon cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, investigations in laryngocarcinoma have elucidated an oncogenic role for miR‑5000‑3p. Here, the long noncoding RNA MIR22HG, which normally acts as a tumor suppressor, functions by sponging miR‑5000‑3p, thereby restraining its activity. When MIR22HG is downregulated—partly due to transcriptional inhibition by E2F6—miR‑5000‑3p levels rise, leading to the repression of the downstream target FBXW7, a gene crucial for inhibiting cell proliferation and migration. Consequently, elevated miR‑5000‑3p contributes to enhanced tumor cell proliferation and migration in laryngocarcinoma, underscoring its potential as an oncogenic driver in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhong-Sheng Xia, Lin Wang, Tao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3232"}], "href": "https://doi.org/10.3892/or.2014.3232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24898979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24898979"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Chen, Mudunov Ali, Azizyan Ruben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00496-19"}], "href": "https://doi.org/10.1128/MCB.00496-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32094308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32094308"}]}]}]}