{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts—which extensively investigate the immunopathogenesis of central nervous system demyelination, primarily focusing on myelin oligodendrocyte glycoprotein (MOG) antigen recognition, T‐ and B‐cell responses, antigen processing pathways, and myelin repair mechanisms in models of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE)—reveals no direct mention or evaluation of microRNA MIR5002. In these studies, detailed insights are offered into how MOG‐specific responses mediate inflammatory demyelination, alter cytokine profiles, and participate in antigen presentation, yet none of the reports include data regarding the expression, regulation, or functional role of MIR5002 in modulating these immune processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn conclusion, while these abstracts underscore the complex immunological circuits involved in CNS autoimmunity and identify several potential therapeutic targets by dissecting MOG‐related immune cascades, the functional role of MIR5002 is not addressed in any of the reports. As a result, no evidence is available from the current collection of studies linking MIR5002 to the modulation of autoimmunity, myelin integrity, or neuroinflammatory processes. Future research explicitly focused on microRNAs will be required to determine if MIR5002 plays any regulatory or mechanistic role in these or related pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Estelle Bettelli, Maria Pagany, Howard L Weiner, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI28330"}], "href": "https://doi.org/10.1172/JCI28330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16955140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16955140"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bernadette Pöllinger, Gurumoorthy Krishnamoorthy, Kerstin Berer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20090299"}], "href": "https://doi.org/10.1084/jem.20090299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19487416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19487416"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stephen Mark Tompkins, Josette Padilla, Mauro C Dal Canto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.168.8.4173"}], "href": "https://doi.org/10.4049/jimmunol.168.8.4173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11937578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11937578"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Cécile Delarasse, Philippe Daubas, Lennart T Mars, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15861"}], "href": "https://doi.org/10.1172/JCI15861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12925695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12925695"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cecilia B Marta, Michael B Montano, Christopher M Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signaling cascades activated upon antibody cross-linking of myelin oligodendrocyte glycoprotein: potential implications for multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413174200"}], "href": "https://doi.org/10.1074/jbc.M413174200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15634682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15634682"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Antonio Carrillo-Vico, Melanie D Leech, Stephen M Anderton "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of myelin autoantigen citrullination to T cell autoaggression in the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903639"}], "href": "https://doi.org/10.4049/jimmunol.0903639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20164413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20164413"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shinya Hirata, Hidetake Matsuyoshi, Daiki Fukuma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of regulatory T cells in the experimental autoimmune encephalomyelitis-preventive effect of dendritic cells expressing myelin oligodendrocyte glycoprotein plus TRAIL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.178.2.918"}], "href": "https://doi.org/10.4049/jimmunol.178.2.918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17202353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17202353"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Patrice H Lalive, Nicolas Molnarfi, Mahdia Benkhoucha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antibody response in MOG(35-55) induced EAE."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2011.09.005"}], "href": "https://doi.org/10.1016/j.jneuroim.2011.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21993076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21993076"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maria Bettini, Kristen Rosenthal, Brian D Evavold "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic MOG-reactive CD8+ T cells require MOG-reactive CD4+ T cells for sustained CNS inflammation during chronic EAE."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2009.05.017"}], "href": "https://doi.org/10.1016/j.jneuroim.2009.05.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19540601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19540601"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "H-Christian von Büdingen, Feng Mei, Ariele Greenfield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201504106"}], "href": "https://doi.org/10.1083/jcb.201504106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26347141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26347141"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Til Menge, Patrice H Lalive, H Christian von Büdingen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1742-2094-8-161"}], "href": "https://doi.org/10.1186/1742-2094-8-161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22093619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22093619"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "David Liñares, Paula Mañá, Melinda Goodyear, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2003.09.001"}], "href": "https://doi.org/10.1016/j.jaut.2003.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14624757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14624757"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "J F Kroepfl, M V Gardinier "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a basolateral membrane targeting signal within the cytoplasmic domain of myelin/oligodendrocyte glycoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1471-4159.2001.00343.x"}], "href": "https://doi.org/10.1046/j.1471-4159.2001.00343.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11389181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11389181"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Cecile Delarasse, Paul Smith, David Baker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/imm.12155"}], "href": "https://doi.org/10.1111/imm.12155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23876060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23876060"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Eitan M Akirav, Yan Xu, Nancy H Ruddle "}, {"type": "b", "children": [{"type": "t", "text": "Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2011.03.013"}], "href": "https://doi.org/10.1016/j.jneuroim.2011.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21550671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21550671"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Richard A O'Connor, Xujian Li, Seth Blumerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1101118"}], "href": "https://doi.org/10.4049/jimmunol.1101118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22287719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22287719"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ahmed H Badawi, Teruna J Siahaan "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of MOG- and PLP-induced experimental autoimmune encephalomyelitis using a novel multivalent bifunctional peptide inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2013.07.009"}], "href": "https://doi.org/10.1016/j.jneuroim.2013.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23911075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23911075"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zivar Salehi, Sara Pishgah Hadiyan, Reza Navidi "}, {"type": "b", "children": [{"type": "t", "text": "Ciliary neurotrophic factor role in myelin oligodendrocyte glycoprotein expression in Cuprizone-induced multiple sclerosis mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Neurobiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10571-013-9918-7"}], "href": "https://doi.org/10.1007/s10571-013-9918-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23443463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23443463"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Joanna Jung, Elzbieta Dudek, Marek Michalak "}, {"type": "b", "children": [{"type": "t", "text": "The role of N-glycan in folding, trafficking and pathogenicity of myelin oligodendrocyte glycoprotein (MOG)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2014.12.023"}], "href": "https://doi.org/10.1016/j.bbamcr.2014.12.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25541284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25541284"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nóra Terényi, Nándor Nagy, Krisztián Papp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transient decomplementation of mice delays onset of experimental autoimmune encephalomyelitis and impairs MOG-specific T cell response and autoantibody production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2008.12.026"}], "href": "https://doi.org/10.1016/j.molimm.2008.12.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19201476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19201476"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Mayumi Fujita, Takao Otsuka, Miho Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via an iNKT cell-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.090265"}], "href": "https://doi.org/10.2353/ajpath.2009.090265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19700760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19700760"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Rubens Murilo Gibaile Soares, Alyria Teixeira Dias, Sandra Bertelli Ribeiro De Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Optical neuritis induced by different concentrations of myelin oligodendrocyte glycoprotein presents different profiles of the inflammatory process."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autoimmunity (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/08916934.2013.796938"}], "href": "https://doi.org/10.3109/08916934.2013.796938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24083391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24083391"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Joanna Jung, Marek Michalak "}, {"type": "b", "children": [{"type": "t", "text": "Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2010.12.014"}], "href": "https://doi.org/10.1016/j.bbamcr.2010.12.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21172390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21172390"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Florent Salvador, Laure Deramoudt, Frédéric Leprêtre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.755900"}], "href": "https://doi.org/10.3389/fimmu.2022.755900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35185870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35185870"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Sharon A Sagan, Zahra Moinfar, Carson E Moseley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2306572120"}], "href": "https://doi.org/10.1073/pnas.2306572120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37463205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37463205"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jie-Yu Chung, William Figgett, Kirsten Fairfax, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2023.114412"}], "href": "https://doi.org/10.1016/j.expneurol.2023.114412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37075967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37075967"}]}]}]}