MIR5003 Gene

Name microRNA 5003
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGastric cancer remains a significant health challenge worldwide, and its progression is closely linked to the process of epithelial-to-mesenchymal transition (EMT), which promotes cancer cell invasion and metastasis. The present study examines the regulatory network involving long non‑coding RNA (lncRNA) RP11‑789C1.1 and its target microRNA, MIR5003, suggesting that MIR5003 plays a pivotal role in modulating EMT by affecting the expression of E‑cadherin—a key molecule responsible for maintaining epithelial integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn this context, MIR5003 is positioned as a crucial mediator within the RP11‑789C1.1 pathway; its regulation appears to alter E‑cadherin levels, thereby facilitating the phenotypic switch from an epithelial to a mesenchymal state integral to tumor progression and metastasis in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nThese findings highlight the importance of MIR5003 as a potential therapeutic target in gastric cancer by illustrating its contribution to the regulatory cascade that drives EMT, underscoring the broader relevance of non‑coding RNA networks in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zehong Chen, Jialin Wu, Wensheng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA RP11-789C1.1 Suppresses Epithelial to Mesenchymal Transition in Gastric Cancer Through the RP11-789C1.1/MiR-5003/E-Cadherin Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000491617"}], "href": "https://doi.org/10.1159/000491617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29991048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29991048"}]}]}]}
NCBI Gene ID 100847029
API
Download Associations
Predicted Functions View MIR5003's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR5003's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR5003's ARCHS4 Predicted Functions.

Functional Associations

MIR5003 has 162 functional associations with biological entities spanning 2 categories (cell line, cell type or tissue, gene, protein or microRNA) extracted from 3 datasets.

Click the + buttons to view associations for MIR5003 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5003 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5003 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR5003 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.