MIR5007 Gene

Name microRNA 5007
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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The study suggests that genetic variations in MIR5007 may contribute to the heterogeneity and predisposition seen in COPD, implying that this miRNA could modulate gene regulatory networks relevant to pulmonary inflammation and cellular homeostasis in the disease process (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amy Tarangelo, Nathanael Lo, Rebecca Teng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-20080-9"}], "href": "https://doi.org/10.1038/s41467-020-20080-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33293536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33293536"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Oxana Bereshchenko, Elena Mancini, Luisa Luciani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pontin is essential for murine hematopoietic stem cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2011.060251"}], "href": "https://doi.org/10.3324/haematol.2011.060251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22371176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22371176"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuanyuan Li, Lu Zhao, Shiaulou Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Axonemal dynein assembly requires the R2TP complex component Pontin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.152314"}], "href": "https://doi.org/10.1242/dev.152314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29113992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29113992"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kyungjin Boo, Jinhyuk Bhin, Yoon Jeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7810"}], "href": "https://doi.org/10.1038/ncomms7810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25857206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25857206"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Claudia Dafinger, Markus M Rinschen, Lori Borgal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-018-0108-z"}], "href": "https://doi.org/10.1038/s12276-018-0108-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29959317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29959317"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tommaso Mello, Maria Materozzi, Francesca Zanieri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.32787"}], "href": "https://doi.org/10.1002/ijc.32787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31721195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31721195"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rui Zhang, Chris Y Cheung, Sang-Uk Seo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.75936"}], "href": "https://doi.org/10.7150/thno.75936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36438486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36438486"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jie Tian, Mingxin Wen, Peng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-024-06651-4"}], "href": "https://doi.org/10.1038/s41419-024-06651-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38609375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38609375"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dan Xu, Jing Jing, Zheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between genetic polymorphisms of miRNAs (miR-8079 and miR-5007) and susceptibility of chronic obstructive pulmonary disease in Chinese people."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microb Pathog (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.micpath.2021.105160"}], "href": "https://doi.org/10.1016/j.micpath.2021.105160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34455057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34455057"}]}]}]}
NCBI Gene ID 100846996
API
Download Associations
Predicted Functions View MIR5007's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR5007's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR5007's ARCHS4 Predicted Functions.

Functional Associations

MIR5007 has 163 functional associations with biological entities spanning 2 categories (cell line, cell type or tissue, gene, protein or microRNA) extracted from 4 datasets.

Click the + buttons to view associations for MIR5007 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5007 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5007 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5007 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR5007 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.