MIR500A Gene

HGNC Family Non-coding RNAs
Name microRNA 500a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR500A, a gene giving rise to several mature microRNA species (including miR‑500, miR‑500a‑3p, and miR‑500a‑5p), is dynamically expressed during development and re‐emerges in certain cancers. In liver, for example, miR‑500 displays oncofetal characteristics: it is abundantly expressed in hepatocellular carcinoma cell lines and patient tissues, with elevated serum levels that normalize following curative surgery, suggesting its utility as a diagnostic biomarker in liver cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, aberrant levels of miR‑500a‑3p have been implicated in modulating key signaling pathways such as JAK/STAT3, thereby contributing to tumor development and progression; its dysregulation underscores not only a role in disease pathogenesis but also a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In a different tumor context, in colorectal cancer miR‑500a‑3p functions as a tumor suppressor—it induces G0/G1 cell cycle arrest and inhibits cell proliferation and migration by directly targeting HDAC2, with its transcription being regulated by the p300/YY1/HDAC2 complex. Therapeutic delivery of miR‑500a‑3p in experimental settings has led to significant tumor growth suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in breast cancer the –5p arm of the MIR500A precursor, miR‑500a‑5p, is elevated in cancer‐associated fibroblasts and their secreted exosomes. This exosomal miR‑500a‑5p is transferred to adjacent tumor cells, where it promotes proliferation and metastasis by targeting ubiquitin‑specific peptidase 28 (USP28). These observations suggest that MIR500A–derived species may have tissue‐ or context‐dependent roles, acting either as oncogenes or tumor suppressors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yusuke Yamamoto, Nobuyoshi Kosaka, Minoru Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/13547500903150771"}], "href": "https://doi.org/10.3109/13547500903150771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19863192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19863192"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chunlin Jiang, Jianting Long, Baoxian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-017-0568-3"}], "href": "https://doi.org/10.1186/s13046-017-0568-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28750679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28750679"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weimei Tang, Weijie Zhou, Li Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-08225-3"}], "href": "https://doi.org/10.1038/s41467-018-08225-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737378"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bing Chen, Yuting Sang, Xiaojin Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.53412"}], "href": "https://doi.org/10.7150/thno.53412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33664871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33664871"}]}]}]}
Synonyms MIR500, HSA-MIR-500A, MIRN500, MIR-500A, HSA-MIR-500
NCBI Gene ID 574502
API
Download Associations
Predicted Functions View MIR500A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR500A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR500A's ARCHS4 Predicted Functions.

Functional Associations

MIR500A has 210 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR500A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR500A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR500A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR500A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR500A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR500A gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR500A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR500A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR500A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR500A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR500A from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR500A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR500A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR500A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR500A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR500A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.