| HGNC Family | Non-coding RNAs |
| Name | microRNA 5047 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that miR-5047 plays a critical role in modulating osteosarcoma cell behavior through its interaction with long noncoding RNA WAC‐AS1. Specifically, miR-5047 normally targets the mRNA of the transcription factor SOX2, serving to suppress its expression and thereby constrain cell proliferation and stemness. However, in osteosarcoma, WAC‐AS1 is highly expressed and acts as a competing endogenous RNA, binding to miR-5047 and sequestering it. This interaction diminishes miR-5047’s inhibitory effect on SOX2, allowing SOX2 levels to rise and promoting enhanced tumor cell proliferation and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the stimulation of SOX2 not only drives oncogenic cell stemness and metastasis but also reinforces a positive feedback mechanism. SOX2 directly binds to the promoter region of WAC‐AS1, further boosting its transcription and perpetuating the cycle of miR-5047 inhibition. Consequently, the WAC‐AS1/miR-5047/SOX2 axis emerges as a pivotal regulatory pathway in osteosarcoma malignancy, highlighting miR-5047’s function as a tumor suppressor that is subverted during disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhining Yang, Zhaoyong Liu, Weiqing Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA WAC-AS1 promotes osteosarcoma Metastasis and stemness by sponging miR-5047 to upregulate SOX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Direct (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13062-023-00433-2"}], "href": "https://doi.org/10.1186/s13062-023-00433-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37957698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37957698"}]}]}]}
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| NCBI Gene ID | 100616408 |
| API | |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR5047 has 1,078 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.
Click the + buttons to view associations for MIR5047 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR5047 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR5047 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR5047 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR5047 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR5047 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR5047 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MIR5047 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR5047 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR5047 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR5047 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR5047 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving MIR5047 protein from the Wikipathways Pathways 2014 dataset. | |
