MIR507 Gene

HGNC Family Non-coding RNAs
Name microRNA 507
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐507 has emerged as an important regulator in cancer biology. In melanoma, miR‑507 directly binds to and is sequestered by the long non‑coding RNA UCA1, resulting in the de‐repression of FOXM1, a key transcription factor that drives cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, miR‑507 similarly exerts tumor‑suppressive effects by targeting Flt‑1, thereby inhibiting invasion and metastasis.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‑small cell lung cancer (NSCLC), multiple studies underscore the significance of miR‑507 in tumor progression. One study demonstrated that the long non‑coding RNA LINC00243 functions as a molecular sponge for miR‑507, leading to upregulation of its downstream target, PDK4, and subsequent promotion of cell proliferation and glycolysis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In another investigation focused on NSCLC chemoresistance, elevated expression of circLRWD1 was found to sequester miR‑507, which in turn resulted in increased SIRT5 expression and enhanced cisplatin resistance. Additional work further confirms that miR‑507 is aberrantly expressed in NSCLC, suggesting its broader involvement in modulating malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer, miR‑507 is also under investigation in other pathological contexts. Recent research is exploring the influence of miR‑507 in preeclampsia, particularly its interplay with CAMK4 in disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, miR‑507 has been confirmed as a tumor inhibitor in several cancer types, and although its function in gastric carcinoma remains to be fully elucidated, the accumulated evidence points to a potential suppressive role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liyan Jia, Wei Liu, Bo Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-507 inhibits the migration and invasion of human breastcancer cells through Flt-1 suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9163"}], "href": "https://doi.org/10.18632/oncotarget.9163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27167339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27167339"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanping Wei, Qianqian Sun, Lindong Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA UCA1-miR-507-FOXM1 axis is involved in cell proliferation, invasion and G0/G1 cell cycle arrest in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-016-0804-2"}], "href": "https://doi.org/10.1007/s12032-016-0804-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27389544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27389544"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xuegang Feng, Shengsheng Yang "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00243 promotes proliferation and glycolysis in non-small cell lung cancer cells by positively regulating PDK4 through sponging miR-507."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-019-03635-3"}], "href": "https://doi.org/10.1007/s11010-019-03635-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31595421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31595421"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "H-L Lv, Z-L Li, Y-B Song "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-507 represses the malignant behaviors of non-small cell lung cancer via targeting zinc finger E-box binding homeobox 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201911_19562"}], "href": "https://doi.org/10.26355/eurrev_201911_19562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31799665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31799665"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhongbiao Deng, Qimin Tu, Guoliang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of circLRWD1 weakens DDP resistance via reduction of SIRT5 expression through releasing miR-507 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000001364"}], "href": "https://doi.org/10.1097/CAD.0000000000001364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35946561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35946561"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "H-Q Li, J-J Fan, X-H Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21477"}], "href": "https://doi.org/10.26355/eurrev_202006_21477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572897"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xin Fang, Anping Pan "}, {"type": "b", "children": [{"type": "t", "text": "MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/β-catenin and HIF-1α pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-022-02862-3"}], "href": "https://doi.org/10.1007/s12094-022-02862-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35819589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35819589"}]}]}]}
Synonyms MIRN507, MIR-507, HSA-MIR-507
NCBI Gene ID 574512
API
Download Associations
Predicted Functions View MIR507's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR507's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR507's ARCHS4 Predicted Functions.

Functional Associations

MIR507 has 165 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR507 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR507 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR507 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR507 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR507 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR507 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR507 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR507 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR507 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR507 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR507 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR507 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR507 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.