{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study investigated the role of the non-coding RNA SLC16A1‑AS1 and its interplay with miR‑5088‑5p in oral squamous cell carcinoma (OSCC). Analysis of OSCC patient tissues revealed that although the levels of SLC16A1‑AS1 and premature miR‑5088‑5p were reduced, there was an increase in the mature form of miR‑5088‑5p. This observation suggests that the maturation process of miR‑5088‑5p is enhanced in OSCC, thereby contributing to the oncogenic profile of the tumor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDis primis duis mauris potenti non at sociosqu ultricies massa. Experimental approaches, including cellular fractionation and RNA pull‑down assays, demonstrated that SLC16A1‑AS1 localizes to both the nucleus and cytoplasm and directly binds to premature miR‑5088‑5p, inhibiting its processing to the mature, oncogenic form. This mechanistic insight underscores the critical regulatory role of SLC16A1‑AS1 in modulating miR‑5088‑5p maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nFusce class lectus fringilla commodo sit blandit pellentesque. Functional assays further revealed that overexpression of SLC16A1‑AS1 suppresses cell proliferation by negatively regulating the conversion of miR‑5088‑5p into its mature state. In effect, the oncogenic potential of mature miR‑5088‑5p is mitigated, positioning the SLC16A1‑AS1/miR‑5088‑5p axis as a promising therapeutic target for controlling OSCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tiecheng Li, Di Wang, Shuo Yang "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the subcellular location of lncRNA SLC16A1-AS1 and its interaction with premature miR-5088-5p in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Odontology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10266-022-00712-w"}], "href": "https://doi.org/10.1007/s10266-022-00712-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35829849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35829849"}]}]}]}