MIR5100 Gene

Name microRNA 5100
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies in lung cancer have revealed that miR‑5100 is aberrantly overexpressed and functions as an oncogenic regulator. In lung cancer tissues and cell lines, elevated miR‑5100 levels promote cell proliferation, colony formation, and tumor growth by facilitating the G1/S cell cycle transition. Mechanistic investigations identified Rab6 as a direct target of miR‑5100, with its inhibition contributing to these oncogenic effects. In addition, heightened miR‑5100 expression has been detected in lung cancer stem cells, where it enhances cancer stem cell properties and mediates resistance to cisplatin by reducing mitochondrial apoptosis, and may also serve as a potential prognostic marker in non‑small cell lung cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other tumor types, miR‑5100 appears to exhibit context‑dependent roles. In pancreatic cancer, overexpression of miR‑5100 was found to suppress metastatic behaviors such as cell migration and invasion by directly targeting podocalyxin‑like 1, thereby revealing an anti‑metastatic function. In gastric cancer, miR‑5100 targets genes (including DEK) to modulate autophagy and apoptosis through the AMPK/mTOR signaling pathway, while additional reports indicate that miR‑5100 may also influence the proliferation of cancer cells and the differentiation of osteoblasts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer, miR‑5100 has emerged as a promising biomarker in several non‑malignant clinical settings. In systemic lupus erythematosus, altered serum miR‑5100 levels correlate with disease activity, suggesting potential utility in diagnosis and disease monitoring. In acute kidney injury models, reduced renal and serum miR‑5100 expression is associated with enhanced apoptosis and tissue damage, while administration of miR‑5100 mimics offers protection against injury. Furthermore, decreased plasma miR‑5100 levels in childhood acute lymphocytic leukemia have been linked to disease risk, underlining its potential as a non‑invasive diagnostic indicator."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haili Huang, Yun Jiang, Yahong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-5100 promotes tumor growth in lung cancer by targeting Rab6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.03.004"}], "href": "https://doi.org/10.1016/j.canlet.2015.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25754817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25754817"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "T Wang, X Liu, Q Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increasing expression of miR-5100 in non-small-cell lung cancer and correlation with prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28925485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28925485"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lawei Yang, Ziying Lin, Yahong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22765"}], "href": "https://doi.org/10.1002/mc.22765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29144562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29144562"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoshiro Chijiiwa, Taiki Moriyama, Kenoki Ohuchida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3389"}], "href": "https://doi.org/10.3892/ijo.2016.3389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26892887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26892887"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hui-Min Zhang, Hui Li, Gen-Xin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2020.03.001"}], "href": "https://doi.org/10.1016/j.neo.2020.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32315812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32315812"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Huimin Zhang, Jun Wang, Yundan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23094787"}], "href": "https://doi.org/10.3390/ijms23094787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35563178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35563178"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "D M Yuan, S Y Wu, S L Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association between expression of plasma miRNA and the risk of childhood acute lymphocytic leukemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Liu Xing Bing Xue Za Zhi (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.0254-6450.2017.09.022"}], "href": "https://doi.org/10.3760/cma.j.issn.0254-6450.2017.09.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28910942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28910942"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Li Zeng, Jia-Li Wu, Li-Min Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clim.2018.10.004"}], "href": "https://doi.org/10.1016/j.clim.2018.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30304699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30304699"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Akinori Aomatsu, Shohei Kaneko, Katsunori Yanai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA expression profiling in acute kidney injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2021.11.010"}], "href": "https://doi.org/10.1016/j.trsl.2021.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34871811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34871811"}]}]}]}
NCBI Gene ID 100847014
API
Download Associations
Predicted Functions View MIR5100's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR5100's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR5100's ARCHS4 Predicted Functions.

Functional Associations

MIR5100 has 400 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR5100 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5100 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR5100 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR5100 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5100 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR5100 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR5100 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR5100 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5100 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR5100 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.