MIR512-2 Gene

HGNC Family Non-coding RNAs
Name microRNA 512-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEpigenetic reactivation studies in gastric cancer and investigations in hepatocellular carcinoma have revealed that members of the miR‐512 family act as tumor suppressors by promoting apoptosis. In gastric cancer cells, treatment with a DNA demethylating agent and an HDAC inhibitor reactivates a normally silenced miR‐512 (specifically the 5p arm), which in turn suppresses the anti‐apoptotic protein Mcl‐1 and induces programmed cell death. Similarly, in hepatocellular carcinoma cells, the 3p arm of miR‐512 downregulates the anti‐apoptotic regulator c‐FLIP, thereby enhancing taxol‐induced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its pro‐apoptotic influence, miR‐512 also plays a significant role in modulating cellular proliferation and drug sensitivity in lung cancers. In lung adenocarcinoma, a circular RNA (hsa_circ_0005576) functions as a molecular sponge for miR‐512 (specifically the 5p form), leading to derepression of IGF1R and contributing to resistance against the EGFR‐TKI osimertinib. Likewise, in non‐small cell lung cancer, aberrant regulation of miR‐512 by lncRNA NCK1‐AS1 affects the p21 pathway, thereby influencing cell cycle progression, proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, recent work aimed at identifying a microRNA signature in liquid biopsies for predicting sorafenib response in hepatocellular carcinoma underscores the potential diagnostic and therapeutic relevance of miR‐512 family members, although this study did not detail their mechanistic roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Saito, H Suzuki, H Tsugawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.140"}], "href": "https://doi.org/10.1038/onc.2009.140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19503096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19503096"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feng Chen, Hai-Hong Zhu, Lin-Fu Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of c-FLIP expression by miR-512-3p contributes to taxol-induced apoptosis in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or_00000784"}], "href": "https://doi.org/10.3892/or_00000784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20372864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20372864"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiping Luo, Juan Zhou, Lingli Quan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2020.153157"}], "href": "https://doi.org/10.1016/j.prp.2020.153157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32858372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32858372"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Suo Liu, Zhibin Jiang, Peng Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0005576 promotes osimertinib resistance through the miR-512-5p/IGF1R axis in lung adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15177"}], "href": "https://doi.org/10.1111/cas.15177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34706132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34706132"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Patricia de la Cruz-Ojeda, Tobias Schmid, Loreto Boix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11172673"}], "href": "https://doi.org/10.3390/cells11172673"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36078082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36078082"}]}]}]}
Synonyms MIRN512-2, MIR-512-2
NCBI Gene ID 574459
API
Download Associations
Predicted Functions View MIR512-2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR512-2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR512-2's ARCHS4 Predicted Functions.

Functional Associations

MIR512-2 has 226 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR512-2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR512-2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR512-2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR512-2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR512-2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR512-2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR512-2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR512-2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR512-2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR512-2 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR512-2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR512-2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR512-2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR512-2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR512-2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.