MIR513A1 Gene

HGNC Family Non-coding RNAs
Name microRNA 513a-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe MIR513A1 microRNA family, which includes isoforms such as miR‐513a‐3p and miR‐513a‐5p, is emerging as a critical post‐transcriptional regulator that binds target mRNAs’ 3′ untranslated regions to modulate a spectrum of cellular processes including differentiation, proliferation, and apoptosis. In reproductive physiology, for example, miR‐513a‐3p directly targets the luteinizing hormone/choriogonadotropin receptor (LHCGR) in human primary granulosa cells, thereby fine‐tuning hormonal signaling (​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in kidney cells, miR‐513a‐5p has been shown to promote apoptosis by targeting anti‐apoptotic factors such as Bcl‐2, underscoring its role in mediating responses to cellular stress (​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancer contexts, aberrant expression and regulation of MIR513A1 isoforms contribute to tumor progression and therapeutic resistance through diverse mechanisms. For instance, in renal cell carcinoma, circMYLK acts as a competing endogenous RNA that sequesters miR‐513a‐5p, leading to enhanced VEGFC expression and tumorigenesis (​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In clear cell renal cell carcinoma, dysregulation by lncRNA MIR4435-2HG suppresses miR‐513a‐5p function to modulate the expression of regulatory proteins such as KLF6 (​"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in gastric cancer, circBFAR sponges miR‐513a‐3p to promote hexokinase 2-driven glycolysis and cell proliferation (​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in cholangiocarcinoma, TTN-AS1 promotes tumor cell growth by sequestering miR‐513a‐5p to regulate stratifin, and in hepatocellular carcinoma, circ_0003998 elevates chemoresistance to 5-fluorouracil through a miR‐513a‐5p/ARK5 axis (​"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", ​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have highlighted the context-dependent roles of MIR513A1 in modulating cell survival and apoptotic pathways. In nephroblastoma cells, lncRNA DLEU1 regulates the miR‐513a‐5p/RANBP2 axis to promote cell proliferation and inhibit apoptosis (​"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and investigations in ovarian cancer have begun to elucidate the functions of miR‐513a‐3p in tumor cell behavior (​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In lung epithelial cells, miR‐513a‐3p enhances x-ray–induced apoptosis by suppressing GSTP1 expression (​"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", whereas in leukemia models, a circRNA derived from CNOT2 modulates the miR‐513a‐5p/CASP8 axis to influence apoptotic responses (​."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings underscore the versatile roles of MIR513A1 in orchestrating key signaling networks in both normal physiology and oncogenesis and highlight its potential as a biomarker and therapeutic target.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "B Troppmann, N Kossack, V Nordhoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-513a-3p acts as a co-regulator of luteinizing hormone/chorionic gonadotropin receptor gene expression in human granulosa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2014.04.003"}], "href": "https://doi.org/10.1016/j.mce.2014.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24747085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24747085"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sheng Li, Ya-Nan Xu, Xi Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-513a-5p targets Bcl-2 to promote dichlorvos induced apoptosis in HK-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.09.101"}], "href": "https://doi.org/10.1016/j.biopha.2018.09.101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30372899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30372899"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianfa Li, ChenChen Huang, Yifan Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15308"}], "href": "https://doi.org/10.1111/jcmm.15308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32342645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32342645"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kai Zhu, Chenkui Miao, Ye Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA MIR4435-2HG promoted clear cell renal cell carcinoma malignant progression via miR-513a-5p/KLF6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15609"}], "href": "https://doi.org/10.1111/jcmm.15609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33460239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33460239"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuning Wang, Bo Cao, Ruiyang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.04.131"}], "href": "https://doi.org/10.1016/j.bbrc.2021.04.131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33979737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33979737"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yang Liu, Jiangyang Sun, Peng Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2011014"}], "href": "https://doi.org/10.1080/21655979.2021.2011014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34903127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34903127"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Liang Xue, Jiefeng He, Haiyun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil resistance in hepatocellular carcinoma through binding to miR-513a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000001359"}], "href": "https://doi.org/10.1097/CAD.0000000000001359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36255069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36255069"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "J L Zhao, L L Zhao, W Z Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112152-20200311-00194"}], "href": "https://doi.org/10.3760/cma.j.cn112152-20200311-00194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33113626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33113626"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y Chen, X-H Zhao, D-D Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-513a-3p inhibits EMT mediated by HOXB7 and promotes sensitivity to cisplatin in ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202010_23389"}], "href": "https://doi.org/10.26355/eurrev_202010_23389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33155195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33155195"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hui Zhou, Binghua Yao, Lulu Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-513a-3p promotes radiation-induced apoptosis of human lung cells by inhibiting glutathione S-transferase P1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmazie (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1691/ph.2022.1872"}], "href": "https://doi.org/10.1691/ph.2022.1872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35459441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35459441"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiajing Li, Yiyu Zhang, Ning Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Zhejiang Univ Sci B (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1631/jzus.B2200048"}], "href": "https://doi.org/10.1631/jzus.B2200048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36111570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36111570"}]}]}]}
Synonyms MIRN513-1, MIRN513A1
NCBI Gene ID 574509
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Download Associations
Predicted Functions View MIR513A1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR513A1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR513A1's ARCHS4 Predicted Functions.

Functional Associations

MIR513A1 has 132 functional associations with biological entities spanning 2 categories (functional term, phrase or reference, cell line, cell type or tissue) extracted from 4 datasets.

Click the + buttons to view associations for MIR513A1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GeneRIF Biological Term Annotations biological terms co-occuring with MIR513A1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR513A1 from the GeneSigDB Published Gene Signatures dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR513A1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with MIR513A1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.