{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCurrent studies have revealed that miR‐513a variants serve as important post‐transcriptional regulators in diverse biological contexts. In human granulosa cells, miR‐513a‐3p negatively regulates luteinizing hormone/chorionic gonadotropin receptor (LHCGR) expression by binding to multiple sites within its 3'UTR, thereby modulating receptor levels and impacting reproductive signaling processes. In parallel, in renal cell carcinoma, elevated levels of circMYLK promote tumorigenesis by sponging miR‐513a‐5p, which normally would down‐regulate VEGFC; the sequestration of miR‐513a‐5p leads to increased VEGFC expression, contributing to tumor growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations extend these findings to additional cancer types. In gastric cancer, circBFAR acts as a sponge for miR‐513a‐3p, thereby relieving its suppressive effect on hexokinase 2 (HK2) expression. The resulting upregulation of HK2 not only enhances cancer cell proliferation but also increases glycolytic activity. Similarly, in nephroblastoma, the long non‐coding RNA DLEU1 exerts oncogenic effects by modulating the miR‐513a‐5p/RANBP2 axis—its interaction with miR‐513a‐5p contributes to decreased apoptosis and supports tumor cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a different cellular setting, research in human myeloid leukemia cells (K‑562) has demonstrated that circRNA.0007127 controls apoptosis via the miR‐513a‐5p/CASP8 pathway. Silencing of this circRNA leads to reduced caspase‑8 activation and decreased apoptotic rates, while overexpression of miR‐513a‐5p diminishes CASP8 levels, further underscoring the central role of miR‐513a in regulating cell survival mechanisms. Together, these studies illustrate that miR‐513a variants, modulated by various competing endogenous RNAs, are pivotal in governing key processes such as proliferation, apoptosis, and metabolic reprogramming across distinct disease contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "B Troppmann, N Kossack, V Nordhoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-513a-3p acts as a co-regulator of luteinizing hormone/chorionic gonadotropin receptor gene expression in human granulosa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2014.04.003"}], "href": "https://doi.org/10.1016/j.mce.2014.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24747085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24747085"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianfa Li, ChenChen Huang, Yifan Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15308"}], "href": "https://doi.org/10.1111/jcmm.15308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32342645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32342645"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J L Zhao, L L Zhao, W Z Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112152-20200311-00194"}], "href": "https://doi.org/10.3760/cma.j.cn112152-20200311-00194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33113626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33113626"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuning Wang, Bo Cao, Ruiyang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.04.131"}], "href": "https://doi.org/10.1016/j.bbrc.2021.04.131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33979737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33979737"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiajing Li, Yiyu Zhang, Ning Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Zhejiang Univ Sci B (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1631/jzus.B2200048"}], "href": "https://doi.org/10.1631/jzus.B2200048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36111570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36111570"}]}]}]}