{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐513b‐5p has emerged as a critical regulator in several disease contexts, notably in cancer. In non‐small cell lung cancer (NSCLC), its expression is significantly downregulated, and restoration of miR‐513b‐5p levels suppresses cell proliferation, migration, and invasion while promoting apoptosis by directly targeting HMGB3, thereby acting as a tumor suppressor (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma (HCC), miR‐513b‐5p similarly restrains malignant progression by inhibiting autophagy through downregulation of PIK3R3, leading to reduced LC3‐II and beclin1 levels and decreased cell growth and metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vascular smooth muscle cells, miR‐513b‐5p modulates extracellular remodeling by suppressing the expression of collagen type I chains (COL1A1 and COL1A2) and affecting cell death pathways—including the RIP1‐RIP3‐MLKL cascade and matrix metalloproteinase signaling—which may contribute to the formation and rupture of intracranial aneurysms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Conversely, in the context of breast cancer, the long noncoding RNA LINC00675 acts as a competing endogenous RNA that sequesters miR‐513b‐5p; its downregulation leads to increased miR‐513b‐5p activity, and this axis appears to promote malignant features, suggesting that miR‐513b‐5p might have oncogenic properties in this tissue type."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in lung cancer models using A549 cells, treatment with Solanum lyratum polysaccharide results in upregulation of miR‐513b‐5p, which correlates with reduced cell proliferation, migration, and invasion, and with enhanced apoptosis. These findings underscore the therapeutic potential of modulating miR‐513b‐5p levels to harness its tumor‐suppressive effects in lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiying Wang, Zhaoying Sheng, Yong Cai "}, {"type": "b", "children": [{"type": "t", "text": "Effects of microRNA-513b on cell proliferation, apoptosis, invasion, and migration by targeting HMGB3 through regulation of mTOR signaling pathway in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27921"}], "href": "https://doi.org/10.1002/jcp.27921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30623409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30623409"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Jin, Yilei Liang, Shuyou Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203135"}], "href": "https://doi.org/10.18632/aging.203135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34120890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34120890"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zheng Zheng, Yan Chen, Yinzhou Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-513b-5p targets COL1A1 and COL1A2 associated with the formation and rupture of intracranial aneurysm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-94116-5"}], "href": "https://doi.org/10.1038/s41598-021-94116-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34290266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34290266"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shenglan Fan, Liping Wang "}, {"type": "b", "children": [{"type": "t", "text": "N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-Methyladenosine-regulated LINC00675 suppress the proliferation, migration and invasion of breast cancer cells via inhibiting miR-513b-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2001905"}], "href": "https://doi.org/10.1080/21655979.2021.2001905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34738869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34738869"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuyu Feng, Wei Wang, Conghui Liu "}, {"type": "b", "children": [{"type": "t", "text": "Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2021.67.6.26"}], "href": "https://doi.org/10.14715/cmb/2021.67.6.26"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35818196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35818196"}]}]}]}