{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑513c has emerged as a multifaceted regulator in cancer biology. In glioblastoma, miR‑513c is markedly downregulated compared with normal brain tissues, and its ectopic expression suppresses cell proliferation. Mechanistically, miR‑513c directly targets the low‑density lipoprotein receptor‑related protein 6 (LRP6) mRNA, thereby inhibiting oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neuroblastoma, miR‑513c is also significantly downregulated relative to normal cells, and its re‐expression curtails migration, invasion, and proliferation by directly targeting glutaminase (GLS), further underscoring its tumor‑suppressive role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), the long noncoding RNA FLVCR1‑AS1 is found to be highly upregulated and functions as a competing endogenous RNA by sponging miR‑513c. This sequestration prevents miR‑513c from binding to and degrading MET mRNA, thereby enhancing MET expression and promoting HCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in glioma, the lncRNA LOC728196 is overexpressed and sponges miR‑513c, leading to upregulation of TCF7, which in turn augments cellular proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic contexts, variants of miR‑513c also play roles in non‑malignant conditions. In the labial salivary glands of Sjögren’s syndrome patients, the miR‑513c‑3p variant is significantly overexpressed and directly targets X‑box binding protein‑1s (XBP‑1s), as well as downregulating GRP78—key regulators of proteostasis essential for secretory function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in the context of preeclampsia, a candidate variant, miR‑513c‑5p, has been identified as a potential regulator of LRP6 mRNA, suggesting its involvement in placental function and the disease’s pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiajun Xu, Tao Sun, Xuebing Hu "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-513c suppresses the proliferation of human glioblastoma cells by repressing low-density lipoprotein receptor-related protein 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.3913"}], "href": "https://doi.org/10.3892/mmr.2015.3913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26063413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26063413"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong-Liang Xia, Yao Lv, Chun-Wei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-170577"}], "href": "https://doi.org/10.3233/CBM-170577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28800318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28800318"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kunsong Zhang, Zhenxian Zhao, Junfeng Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA FLVCR1-AS1 acts as miR-513c sponge to modulate cancer cell proliferation, migration, and invasion in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26802"}], "href": "https://doi.org/10.1002/jcb.26802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29574975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29574975"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ouyang Wang, Yuenuo Huang, Hao Wu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "hsa-miR-424-5p and hsa-miR-513c-3p dysregulation mediated by IFN-γ is associated with salivary gland dysfunction in Sjögren's syndrome patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2023.103037"}], "href": "https://doi.org/10.1016/j.jaut.2023.103037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37229808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37229808"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qian Zhou, Hongyan Li, Yan Zhang, et al. 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