MIR514A3 Gene

HGNC Family Non-coding RNAs
Name microRNA 514a-3
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐514a-3p has emerged as an important regulator in cancer biology. In melanoma, it is highly expressed compared with other solid tumors and targets several genes—including CTNNB1, CDK2, MC1R, NF1—thereby influencing cell survival and contributing to resistance against RAF‐targeted therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In testicular germ cell tumors, miR‐514a-3p induces apoptosis by directly regulating the expression of PEG3, which in turn modulates NF-κB signaling; loss of miR‐514a-3p expression leads to PEG3 upregulation and enhanced NF-κB activity, promoting tumor cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in tumor biology, miR‐514a-3p functions as a critical modulator of growth factor signaling in other tissues. In human placental tissue, it directly targets PTPN11—the gene encoding SHP-2—thereby regulating insulin-like growth factor signaling and trophoblast proliferation. Similarly, in Wilms’ tumor, the lncRNA OSTM1-AS1 acts as a sponge for miR‐514a-3p, ultimately affecting the expression of MELK and influencing tumor cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncogenesis, miR‐514a-3p has been implicated in neural regenerative processes. In studies using human oral mucosa stem cells, this microRNA, in connection with SHP-2 regulation, contributed to the improved survival of anoxia-damaged neurons and functional recovery in stroke models. The regenerative capability mediated by miR‐514a-3p appears to be time-restricted, highlighting its potential for therapeutic strategies in neurological repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mitchell S Stark, Vanessa F Bonazzi, Glen M Boyle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3924"}], "href": "https://doi.org/10.18632/oncotarget.3924"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25980496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25980496"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Deniz Mahmut Özata, Xidan Li, Linkiat Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2016.464"}], "href": "https://doi.org/10.1038/cddis.2016.464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28471449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28471449"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rachel C Quilang, Sylvia Lui, Karen Forbes "}, {"type": "b", "children": [{"type": "t", "text": "miR-514a-3p: a novel SHP-2 regulatory miRNA that modulates human cytotrophoblast proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JME-21-0175"}], "href": "https://doi.org/10.1530/JME-21-0175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34792485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34792485"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jun Du, Jingjing Xiao, Yingquan Zhuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000001320"}], "href": "https://doi.org/10.1097/CAD.0000000000001320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35946509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35946509"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Paula Stančin, Min Suk Song, Ivan Alajbeg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Neurobiol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10571-022-01276-7"}], "href": "https://doi.org/10.1007/s10571-022-01276-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36083390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36083390"}]}]}]}
Synonyms MIR514-3, MIRN514-3, HSA-MIR-514A-3
NCBI Gene ID 574518
API
Download Associations
Predicted Functions View MIR514A3's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR514A3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR514A3's ARCHS4 Predicted Functions.

Functional Associations

MIR514A3 has 143 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 5 datasets.

Click the + buttons to view associations for MIR514A3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR514A3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR514A3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR514A3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR514A3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR514A3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.