MIR514B Gene

HGNC Family Non-coding RNAs
Name microRNA 514b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that MIR514B, which generates two mature microRNA isoforms—miR-514b‑3p and miR‑514b‑5p—exerts diverse, context‐dependent roles across several cancers. These isoforms function via distinct downstream targets and signaling pathways to modulate tumor cell migration, invasion, proliferation, epithelial‐to‐mesenchymal transition (EMT), and drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer (CRC), the miR‑514b‑3p and miR‑514b‑5p forms display opposing functions. miR‑514b‑3p is significantly down‐regulated in CRC tissues and, when active, acts to restrain tumor cell migration, invasion, and chemoresistance by enhancing epithelial markers and reducing mesenchymal markers. In contrast, miR‑514b‑5p promotes EMT and metastasis, as its overexpression accelerates tumor dissemination in in vivo models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn esophageal carcinoma, miR‑514b‑3p is regulated by long non‑coding RNA DDX11‑AS1, which exerts an oncogenic function by sponging miR‑514b‑3p and thereby impairing its ability to suppress the expression of RING box protein 1 (RBX1). The resulting derepression of RBX1 contributes to enhanced tumor growth and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGastric cancer studies have further revealed the complexity of miR‑514b‑3p regulation. One investigation demonstrated that lncRNA‑p21 acts as a molecular sponge for miR‑514b‑3p, leading to an upregulation of ARHGEF9—a tumor suppressor whose decreased expression correlates with increased cell proliferation and reduced apoptosis. In a separate study, elevated levels of exosomal circRNA hsa_circ_0014606 were associated with reduced miR‑514b‑3p and increased expression of heterogeneous nuclear ribonucleoprotein C (HNRNPC), supporting a role for this axis in promoting gastric cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, in non‑small cell lung cancer (NSCLC), miR‑514b‑5p is markedly up‑regulated in tumors and correlates with poorer overall survival. Functional studies indicate that miR‑514b‑5p enhances NSCLC cell growth and suppresses apoptosis by activating the PI3K/AKT and p38 signaling pathways via targeting small glutamine‑rich tetratricopeptide repeat‑containing protein beta (SGTB)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin-Lin Ren, Ting-Ting Yan, Chao-Qin Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0732-5"}], "href": "https://doi.org/10.1038/s41419-018-0732-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29880874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29880874"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chao Wu, Zhibin Wang, Xuetao Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1940617"}], "href": "https://doi.org/10.1080/21655979.2021.1940617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34281459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34281459"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaobin Ma, Wenyu Yan, Peng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-p21 suppresses cell proliferation and induces apoptosis in gastric cancer by sponging miR-514b-3p and up-regulating ARHGEF9 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2022-0153"}], "href": "https://doi.org/10.1515/hsz-2022-0153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35947460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35947460"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tao Jiang, Lingling Xu, Xiaona Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-023-08254-z"}], "href": "https://doi.org/10.1007/s10620-023-08254-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38217675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38217675"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lin Shi, Jun Kan, Lin Zhuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.16639"}], "href": "https://doi.org/10.1111/febs.16639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36180981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36180981"}]}]}]}
Synonyms MIR-514B
NCBI Gene ID 100422847
API
Download Associations
Predicted Functions View MIR514B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR514B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR514B's ARCHS4 Predicted Functions.

Functional Associations

MIR514B has 164 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR514B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR514B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR514B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR514B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR514B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR514B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR514B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR514B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR514B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR514B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR514B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.