MIR515-2 Gene

HGNC Family Non-coding RNAs
Name microRNA 515-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In breast cancer, disruption of its binding to the igf‐1r 3′‐UTR by a single nucleotide polymorphism results in increased IGF‐1R protein levels, which correlates with earlier disease onset. In colorectal cancer, miR‐515‐5p directly targets MAD2L1, and its overexpression leads to cell cycle arrest at the G1 phase and induces apoptosis. Moreover, members of the miR‐515 family (including miR‐515‐3p) have been implicated in gastric cancer development, underscoring the broad impact of these microRNAs on oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRegulatory mechanisms affecting miR‐515‐5p activity also include sequestration by circular RNAs. In prostate cancer, circ‐PAPPA acts as a sponge for miR‐515‐5p, leading to elevated expression of FKBP1A and enhanced malignant phenotypes. Similarly, in cutaneous squamous cell carcinoma, circ‐LARP1B sequesters miR‐515‐5p, which results in the upregulation of TPX2, thereby promoting cell proliferation, migration, and glycolytic metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these oncological settings, miR‐515‐5p also mediates important functions in other disease states. In ovarian cancer, exosomal circTMCO3 derived from M2 macrophages decreases miR‐515‐5p levels, facilitating the upregulation of ITGA8 and promoting tumor progression. In the context of preeclampsia, miR‐515‐5p is found at elevated levels in maternal serum, and its overexpression in trophoblast cells suppresses XIAP expression, thereby inhibiting cell proliferation and invasion. Likewise, in osteoarthritis, miR‐515‐5p contributes to the inhibition of chondrocyte apoptosis and alleviation of inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Li, Zhiyuan Tang, Haiying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.11.004"}], "href": "https://doi.org/10.1016/j.biopha.2017.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29136957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29136957"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun-Sheng Ni, Hao Zheng, Yang-Liu Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-515-5p suppresses HCC migration and invasion via targeting IL6/JAK/STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Surg Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.suronc.2020.03.003"}], "href": "https://doi.org/10.1016/j.suronc.2020.03.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32891315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32891315"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Avital Gilam, Liat Edry, Efrat Mamluk-Morag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-013-2502-5"}], "href": "https://doi.org/10.1007/s10549-013-2502-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23549953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23549953"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang Ding, Qingyan Fu, Weixing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting of MAD2L1 by miR-515-5p involves the regulation of cell cycle arrest and apoptosis of colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11774"}], "href": "https://doi.org/10.1002/cbin.11774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35143103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35143103"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xue Han, Xing Li, Hengyu Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miR-515-3p, a potential new RNA biomarker, is involved in gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28854"}], "href": "https://doi.org/10.1002/jcb.28854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31081157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31081157"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guangwen Wang, Haiyang Zhao, Xiaohong Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Andrologia (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/and.14227"}], "href": "https://doi.org/10.1111/and.14227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34469009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34469009"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lipeng Wang, Shaozhang Hou, Jianning Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2019172"}], "href": "https://doi.org/10.1080/21655979.2021.2019172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34982022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34982022"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiao-Min Ran, Juan Yang, Zi-Yi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-024-06095-8"}], "href": "https://doi.org/10.1038/s42003-024-06095-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38755265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38755265"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Misa Nunode, Masami Hayashi, Yoko Nagayasu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-515-5p suppresses trophoblast cell invasion and proliferation through XIAP regulation in preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2022.111779"}], "href": "https://doi.org/10.1016/j.mce.2022.111779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36155776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36155776"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dongfeng Cai, Zixiao Yang, Chao Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[miR-515-5p targeting Toll-like receptor 4 regulates myeloid differentiation primary response gene 88/nuclear factor-kappa B pathway to inhibit apoptosis and inflammatory response of osteoarthritis chondrocytes]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7507/1002-1892.202312091"}], "href": "https://doi.org/10.7507/1002-1892.202312091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38500425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38500425"}]}]}]}
Synonyms MIRN515-2
NCBI Gene ID 574465
API
Download Associations
Predicted Functions View MIR515-2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR515-2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR515-2's ARCHS4 Predicted Functions.

Functional Associations

MIR515-2 has 187 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR515-2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR515-2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR515-2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR515-2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR515-2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR515-2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR515-2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR515-2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR515-2 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR515-2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR515-2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR515-2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.