MIR516A1 Gene

HGNC Family Non-coding RNAs
Name microRNA 516a-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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This suppression of PHLPP2 leads to reduced stabilization of BECN1 and autophagy, thereby promoting tumor cell growth both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, elevated levels of miR‐516a (specifically the 3P species) have been observed in hepatocellular carcinoma compared with hepatitis C virus infection, with expression correlating with genetic factors such as the PNPLA3 rs738409 GG genotype. These findings suggest that MIR516A1 may serve as a potential biomarker for HCC and be implicated in hepatocarcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, overexpression of hsa‐miR‐516a‐5p has been shown to significantly impact the migratory and invasive abilities of tumor cells, further supporting the role of MIR516A1 as an important regulator of tumor progression and metastasis in central nervous system cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Charles-Henry Gattolliat, Gwénaël Le Teuff, Valérie Combaret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.264"}], "href": "https://doi.org/10.1002/cam4.264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24931722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24931722"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Honglei Jin, Jiugao Ma, Jiheng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic role of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MIR516A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2020.1733262"}], "href": "https://doi.org/10.1080/15548627.2020.1733262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32116109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32116109"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Samar Samir Youssef, Rana Ahmed Youness, Eman Abd El-Razek Abbas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-516a-3P, a potential circulating biomarker in hepatocellular carcinoma, correlated with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "rs738409"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " polymorphism in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PNPLA3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Per Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/pme-2022-0005"}], "href": "https://doi.org/10.2217/pme-2022-0005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36239555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36239555"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ángela Y García Fonseca, Yeimy González-Giraldo, Jannet Gonzalez Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The hsa-miR-516a-5p and hsa-miR-516b-5p microRNAs reduce the migration and invasion on T98G glioblastoma cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2022.11.002"}], "href": "https://doi.org/10.1016/j.cancergen.2022.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36410106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36410106"}]}]}]}
Synonyms MIR-516A-1, MIRN516-1, MIRN516A1, MIRN516A-1
NCBI Gene ID 574498
API
Download Associations
Predicted Functions View MIR516A1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR516A1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR516A1's ARCHS4 Predicted Functions.

Functional Associations

MIR516A1 has 188 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR516A1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR516A1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR516A1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR516A1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR516A1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR516A1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR516A1 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR516A1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR516A1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR516A1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.