{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR517C, a microRNA belonging to the C19MC cluster, exhibits context‐dependent regulatory roles in cellular homeostasis and disease. In primary central nervous system primitive neuroectodermal tumors, MIR517C is strikingly overexpressed due to a high‐level amplicon and acts as an oncogene by promoting cell survival, proliferation, and anchorage‐independent growth of human neural stem cells through mechanisms that include upregulation of the WNT pathway and inhibition of differentiation. In parallel, studies in hepatocellular carcinoma have shown that ectopic expression of MIR517C impedes cell proliferation by enforcing a G2/M cell cycle arrest via targeting of proteins such as Pyk2, with its downregulation contributing to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disparate yet critical functions of MIR517C are also evident in the regulation of cellular invasion and stress responses. In placental trophoblasts, MIR517C expression is induced under hypoxic conditions and is implicated in the pathogenesis of preeclampsia by reducing trophoblast invasion and enhancing the expression of anti-angiogenic factors. Similarly, in glioblastoma cells harboring wild-type TP53, MIR517C suppresses autophagy and cellular migration by degrading KPNA2 and disrupting the nuclear translocation of TP53, thereby preventing the epithelial-to-mesenchymal transition and correlating with improved patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meihua Li, Kyle F Lee, Yuntao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2009.10.025"}], "href": "https://doi.org/10.1016/j.ccr.2009.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19962671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19962671"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rui-Fang Liu, Xiao Xu, Jian Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2012.10.027"}], "href": "https://doi.org/10.1016/j.canlet.2012.10.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23142219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23142219"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lauren Anton, Anthony O Olarerin-George, John B Hogenesch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0122707"}], "href": "https://doi.org/10.1371/journal.pone.0122707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25799546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25799546"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuntao Lu, Limin Xiao, Yawei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2015.1108507"}], "href": "https://doi.org/10.1080/15548627.2015.1108507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26553592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26553592"}]}]}]}