{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-5189-3p has emerged as a potentially critical regulatory molecule in distinct pathological processes. In one study investigating deep vein thrombosis (DVT) in the lower extremity, the authors examined the role and underlying mechanisms of miR-5189-3p. Although the study primarily focused on exploring its contribution to thrombotic events, it underscored the microRNA’s importance in vascular pathology, prompting further inquiry into its mechanistic functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In another study focused on laryngeal squamous cell carcinoma (LSCC), miR-5189-3p was found to be significantly down-regulated in tumor tissues and cell lines. Functional assays demonstrated that restoration of miR-5189-3p markedly inhibited cell proliferation, migration, and invasion. Mechanistically, miR-5189-3p exerts its tumor-suppressive effects by directly targeting and down-regulating EIF5A2, a gene implicated in promoting oncogenesis; reintroduction of EIF5A2 was able to rescue the tumor cells from the inhibitory effects of miR-5189-3p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Collectively, these studies highlight the multifaceted role of miR-5189-3p as both a potential modulator of thrombotic processes in DVT and a tumor suppressor in LSCC. The emerging evidence supports its candidacy as a promising molecular target for therapeutic intervention across diverse clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Lu, Qingbo Fang, Xiaohu Ge "}, {"type": "b", "children": [{"type": "t", "text": "Role and Mechanism of mir-5189-3p in Deep Vein Thrombosis of Lower Extremities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Vasc Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.avsg.2021.07.004"}], "href": "https://doi.org/10.1016/j.avsg.2021.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34416282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34416282"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dan Lou, Qiaojing Jia, Haizhong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-023-10489-4"}], "href": "https://doi.org/10.1007/s10528-023-10489-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37656330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37656330"}]}]}]}