{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn imatinib mesylate‐resistant gastrointestinal stromal tumors, miR-518a-5p has been shown to suppress tumor cell proliferation and promote apoptosis through direct targeting of the 3′ untranslated region of the gene PIK3C2A. Reduced levels of this miRNA were found to correlate with increased expression of PIK3C2A, which likely contributes to the cellular resistance observed during imatinib treatment. These findings highlight the importance of miR-518a-5p in modulating drug response in GISTs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in GISTs, miR-518a-5p has been implicated in the regulation of the chemokine receptor CCR6, a key player in colorectal cancer progression and diffuse large B cell lymphoma (DLBCL). Functional studies demonstrate that miR-518a-5p negatively regulates CCR6 expression, thereby inhibiting cell proliferation and invasion. In DLBCL, this regulatory relationship is further influenced by epigenetic modifications such as promoter hypermethylation and altered histone acetylation patterns. The modulation of downstream JAK2/STAT6 signaling by these miRNA-CCR6 interactions provides further insight into their roles in tumorigenesis and suggests a feedback loop that contributes to lymphoma development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also underscores the potential significance of miR-518a-5p in other malignancies such as breast cancer, where unraveling its molecular interactions may lead to the identification of novel therapeutic targets. As our understanding of miR-518a-5p’s impact on oncogenic pathways deepens, it may become a critical component in the development of strategies to overcome drug resistance and prevent tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Shi, Xiaodong Gao, Qin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2015.157"}], "href": "https://doi.org/10.1038/labinvest.2015.157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26950487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26950487"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Claudia Rubie, Bianca Kruse, Vilma Oliveira Frick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-12-48"}], "href": "https://doi.org/10.1186/1479-5876-12-48"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24559209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24559209"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qian Huang, Feng Zhang, Haiying Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2020.1786317"}], "href": "https://doi.org/10.1080/15592294.2020.1786317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32600091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32600091"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Wang, Ziru Guo, Shuo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR-518a-5p Targets ZEB2 to Suppress the Migration and Invasion of Breast-cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Altern Ther Health Med (2023)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35986741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35986741"}]}]}]}