MIR518B Gene

HGNC Family Non-coding RNAs
Name microRNA 518b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In this context, upregulation of MIR518B was associated with reduced levels of anti‐apoptotic proteins and increased activity of caspases, suggesting that MIR518B may act to facilitate programmed cell death in tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, in glioblastoma research, restoration of MIR518B expression suppressed cell proliferation and angiogenesis by directly targeting PDGFRB, further reinforcing its potential tumor‐suppressive role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in oncogenesis, MIR518B is widely recognized as a placenta‐associated microRNA with significant roles in early embryonic development. Its aberrant expression has been documented in several gestational pathologies. For instance, one study reported increased MIR518B levels in human villus tissues from cases of early embryonic arrest and demonstrated that MIR518B directly regulates the transcription factor EGR1, affecting cell migration and angiogenesis critical to implantation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, altered expression of MIR518B has been observed in complete hydatidiform mole"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", placenta accreta"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and acute chorioamnionitis where its expression was linked to genetic variants in inflammatory mediators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Plasma levels of MIR518B have also been evaluated in preeclamptic pregnancies, underscoring its emerging potential as a non‐invasive biomarker of placental health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in tumorigenesis and placental pathology, MIR518B participates in regulating epithelial lineage development. In studies of embryonal carcinoma cells differentiating towards an epithelial/smooth muscle phenotype, MIR518B, along with MIR18B, was identified as a key regulator that suppresses the expression of the transcription factor FOXN1, which is required for keratinocyte differentiation and epithelial cell proliferation. The manipulation of MIR518B levels led to corresponding changes in FOXN1 expression and its downstream epithelial markers, thereby demonstrating its pivotal role in epithelial cell fate determination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenna Liang, Xihai Li, Yachan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.2155"}], "href": "https://doi.org/10.3892/ijo.2013.2155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24173143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24173143"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaolong Xu, Fenglin Zhang, Xianzhen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7298"}], "href": "https://doi.org/10.3892/mmr.2017.7298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849154"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenmei Yang, Zhaoyi Lu, Zhifu Zhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrest†."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/biolre/ioz109"}], "href": "https://doi.org/10.1093/biolre/ioz109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31291448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31291448"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Quan Na, Dan Wang, Weiwei Song "}, {"type": "b", "children": [{"type": "t", "text": "Underexpression of 4 placenta-associated microRNAs in complete hydatidiform moles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IGC.0b013e3182574439"}], "href": "https://doi.org/10.1097/IGC.0b013e3182574439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22672989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22672989"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Y Long, Y Chen, X-Q Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Research on the expression of MRNA-518b in the pathogenesis of placenta accreta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201901_16743"}], "href": "https://doi.org/10.26355/eurrev_201901_16743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30657542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30657542"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chaini Konwar, Irina Manokhina, Jefferson Terry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered levels of placental miR-338-3p and miR-518b are associated with acute chorioamnionitis and IL6 genotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2019.05.009"}], "href": "https://doi.org/10.1016/j.placenta.2019.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31174625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31174625"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Munjas Jelena, Miron Sopić, Ivana Joksić, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-specific plasma miR518b is a potential biomarker for preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinbiochem.2020.02.012"}], "href": "https://doi.org/10.1016/j.clinbiochem.2020.02.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32092293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32092293"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ritu Kushwaha, Venkata Thodima, Mark J Tomishima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2013.0262"}], "href": "https://doi.org/10.1089/scd.2013.0262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24383669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24383669"}]}]}]}
Synonyms MIRN518B, MIR-518B
NCBI Gene ID 574474
API
Download Associations
Predicted Functions View MIR518B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR518B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR518B's ARCHS4 Predicted Functions.

Functional Associations

MIR518B has 216 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR518B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR518B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR518B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR518B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR518B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR518B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR518B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR518B from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR518B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR518B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR518B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.