MIR518D Gene

HGNC Family Non-coding RNAs
Name microRNA 518d
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated miR‐518d in the pathogenesis of gestational diabetes mellitus (GDM). In placental tissues from patients with GDM, miR‐518d is significantly upregulated, a change that is inversely correlated with the protein levels of peroxisome proliferator‐activated receptor‐α (PPARα). This microRNA binds directly to a specific seed sequence in the mRNA of PPARα, suggesting that its overexpression may impair normal placental function and contribute to the inflammatory milieu—possibly via effects on the NF‐κB pathway—that underlies GDM pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a distinct clinical context, miR‐518d‐5p has also been shown to play a role in the progression of small cell lung cancer (SCLC). Here, miR‐518d‐5p regulates the expression of key oncogenic mediators, including LIN28B and DLL3, by modulating their mRNA stability. This regulatory axis impacts critical cancer cell features such as proliferation, migration, and epithelial–mesenchymal transition, thereby contributing to chemoresistance and a more aggressive tumor phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chun Zhao, Ting Zhang, Zhonghua Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2014.2058"}], "href": "https://doi.org/10.3892/mmr.2014.2058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24639097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24639097"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Qiu, Xuemin Liu, Shenshen Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation and Mechanism of miR-518d through the PPAR"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "α"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Mediated NF-"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "κ"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "B Pathway in the Development of Gestational Diabetes Mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diabetes Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/7019597"}], "href": "https://doi.org/10.1155/2020/7019597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33123597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33123597"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianling Huang, Dandan Cao, Jun Sha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DLL3 is regulated by LIN28B and miR-518d-5p and regulates cell proliferation, migration and chemotherapy response in advanced small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.130"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31079917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31079917"}]}]}]}
Synonyms MIRN518D
NCBI Gene ID 574489
API
Download Associations
Predicted Functions View MIR518D's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR518D's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR518D's ARCHS4 Predicted Functions.

Functional Associations

MIR518D has 179 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR518D from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518D gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518D gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR518D gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR518D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR518D gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR518D from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR518D gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518D gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR518D gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.