{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn studies of progressive supranuclear palsy it was found that MIR518E is significantly upregulated in patients’ forebrains, where its elevated expression correlates with the repression of several key target genes. Specifically, the targets of MIR518E include CPEB1, JAZF1, and RAP1B, whose down‐regulation is indicative of a microRNA-mediated mechanism that may alter diverse cellular processes. These findings suggest that MIR518E functions as a negative regulator, exerting its effects by binding to and reducing the levels of its target transcripts, thereby potentially contributing to the neuropathological changes observed in the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBy repressing genes implicated in various cellular functions, MIR518E appears to participate in an epigenetic regulatory network that might affect neuronal signaling, survival, or differentiation. Although the precise downstream consequences of MIR518E upregulation remain to be fully elucidated, its significant increase in progressive supranuclear palsy underscores its potential involvement in disease etiology and highlights the importance of further investigation into microRNA-driven modulation of gene expression in neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Roman Tatura, Malte Buchholz, Dennis W Dickson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA profiling: increased expression of miR-147a and miR-518e in progressive supranuclear palsy (PSP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-016-0480-6"}], "href": "https://doi.org/10.1007/s10048-016-0480-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27052995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27052995"}]}]}]}