MIR518F Gene

HGNC Family Non-coding RNAs
Name microRNA 518f
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into placental development have highlighted a potential regulatory role for MIR518F (miR‐518f‐5p), a member of the chromosome 19 miRNA cluster, in modulating angiogenesis. Expression of MIR518F has been correlated with maternal, placental, and neonatal parameters, suggesting that this microRNA may contribute to the regulation of vascular processes in the placenta. In particular, its predicted targeting of key angiogenesis-associated genes—such as ENG (endoglin), VEGF, and FLT—indicates that MIR518F might influence endothelial function and the remodeling of blood vessels, a process critical for proper placental and fetal development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, comparative analyses in full‐term singleton pregnancies, including cohorts of small‐for‐gestational‐age (SGA) and appropriate‐for‐gestational‐age (AGA) newborns, have revealed that the expression of MIR518F may vary with fetal sex and growth parameters. These observations underscore its potential role as a post‐transcriptional modulator of placental angiogenesis, thereby linking microRNA‐mediated regulation to vascular development and, ultimately, to variations in fetal growth outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Prachi Kochhar, Pratibha Dwarkanath, Gayatri Ravikumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental expression of miR-517-5p and miR-518f-5p: Fetal sex-specific relations with human fetoplacental growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2021.12.030"}], "href": "https://doi.org/10.1016/j.ejogrb.2021.12.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34992034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34992034"}]}]}]}
Synonyms MIRN518F
NCBI Gene ID 574472
API
Download Associations
Predicted Functions View MIR518F's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR518F's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR518F's ARCHS4 Predicted Functions.

Functional Associations

MIR518F has 173 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR518F from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518F gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518F gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR518F gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR518F gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR518F gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR518F from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR518F gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR518F gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR518F gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR518F gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.