{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-5191 has emerged as a critical microRNA implicated in the progression of salivary adenoid cystic carcinoma (SACC). Recent work has focused on determining its role in modulating tumor cell behavior, particularly its influence on proliferation, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn SACC models, miR-5191 appears to regulate key pathways that control cell growth and motility. The study indicates that alterations in miR-5191 expression can lead to enhanced tumor cell proliferation and increased invasive potential, suggesting that this microRNA may contribute directly to the metastatic cascade observed in this carcinoma subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese findings underscore the potential of miR-5191 to serve as both a biomarker and a therapeutic target in SACC. By modulating critical aspects of tumor behavior, miR-5191 not only offers insight into the molecular mechanisms underpinning carcinoma aggressiveness but also opens avenues for the development of targeted interventions aimed at mitigating invasion and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi Li, Qian Zhang, Han Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-5191 acts as a tumor suppressor in salivary adenoid cystic carcinoma by targeting Notch-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/odi.13841"}], "href": "https://doi.org/10.1111/odi.13841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33694237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33694237"}]}]}]}