{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-5193 has recently been identified as a potent antiviral microRNA with the capacity to target hepatitis B virus (HBV) transcripts across multiple genotypes. By establishing a highly stable hybridization with HBV RNA, miR-5193 significantly decreases luciferase reporter activity and surface antigen production, indicating its promise as a therapeutic tool to inhibit HBV replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of prostate cancer, miR-5193 has been shown to exert a tumor‐suppressive role by directly targeting the mRNA encoding TRIM11—a pro‐tumorigenic E3 ubiquitin ligase. Overexpression of miR-5193 in prostate cancer cells leads to the downregulation of TRIM11, which in turn correlates with reduced cell proliferation and a potentially more favorable clinical outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in ovarian cancer, miR-5193 functions as an essential inhibitor of tumor progression. It directly targets TRIM11, resulting in decreased expression of this oncogene. This targeting is accompanied by the upregulation of key tumor suppressors such as p53 and p21, ultimately leading to cell cycle arrest, increased apoptosis, and diminished migratory and proliferative capabilities in ovarian cancer cells. These findings not only reinforce the role of miR-5193 in modulating oncogenic pathways but also suggest its potential utility as a downstream regulator in the carcinogenic processes mediated by factors like FUT1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Apichaya Khlaiphuengsin, Nattanan Panjaworayan T-Thienprasert, Pisit Tangkijvanich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human miR-5193 Triggers Gene Silencing in Multiple Genotypes of Hepatitis B Virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microrna (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/2211536604666150819195743"}], "href": "https://doi.org/10.2174/2211536604666150819195743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26456535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26456535"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yue Pan, Riyan Zhang, Hongde Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is Associated with the Progression of Human Prostate Cancer and is Downregulated by MicroRNA-5193."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.911818"}], "href": "https://doi.org/10.12659/MSM.911818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30608062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30608062"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zuofei Song, Qian Guo, Huimin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2020.153148"}], "href": "https://doi.org/10.1016/j.prp.2020.153148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32823233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32823233"}]}]}]}