{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMelanoma is an aggressive skin cancer characterized by increasing rates of morbidity and mortality. Recent studies have uncovered that LINC01063 is markedly upregulated in melanoma tissues—especially in advanced and metastatic cases—highlighting its significant role in disease progression. This long noncoding RNA contributes to melanoma pathology by interacting with key molecular regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nMechanistic investigations reveal that LINC01063 functions as a molecular sponge for miR-5194. Under normal circumstances, miR-5194 negatively regulates the expression of SOX12, a transcription factor involved in tumor cell proliferation, migration, invasion, and epithelial-mesenchymal transition. By sequestering miR-5194, LINC01063 alleviates this suppression, leading to enhanced SOX12 expression and, consequently, promoting the malignant behavior of melanoma cells. These findings support the notion that the LINC01063/miR-5194/SOX12 axis could represent a promising target for therapeutic intervention and a potential prognostic biomarker in melanoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiangmei Xu, Rongying Ou, Gang Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0000000000000803"}], "href": "https://doi.org/10.1097/CMR.0000000000000803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35256570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35256570"}]}]}]}