MIR5196 Gene

Name microRNA 5196
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies indicate that miRNA‑5196 may serve as a dynamic biomarker in immune‐mediated conditions. In patients with rheumatoid arthritis and ankylosing spondylitis, serum levels of miRNA‑5196 are significantly elevated before anti‑TNF‑α therapy, and decreases in its expression closely correlate with improvements in disease activity. This suggests that miRNA‑5196 holds promise for predicting and monitoring therapeutic responses in these inflammatory disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role as a circulating biomarker in rheumatic diseases, genetic variation within the miR‑5196 gene has been implicated in pediatric hematologic malignancies. In particular, the single nucleotide polymorphism rs10406069 in miR‑5196 has been significantly associated with an increased risk of developing hyperdiploid acute lymphoblastic leukemia, possibly through its effect on miRNA expression and the subsequent regulation of target genes such as SMC1A, which is involved in sister chromatid cohesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marzena Ciechomska, Krzysztof Bonek, Michal Merdas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in MiRNA-5196 Expression as a Potential Biomarker of Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Immunol Ther Exp (Warsz) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00005-018-0513-y"}], "href": "https://doi.org/10.1007/s00005-018-0513-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29744553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29744553"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angela Gutierrez-Camino, Chantal Richer, Pascal St-Onge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of rs10406069 in miR-5196 in hyperdiploid childhood acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/epi-2020-0152"}], "href": "https://doi.org/10.2217/epi-2020-0152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33245684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33245684"}]}]}]}
Synonyms MIR-5196
NCBI Gene ID 100847070
API
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Predicted Functions View MIR5196's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR5196's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR5196's ARCHS4 Predicted Functions.

Functional Associations

MIR5196 has 358 functional associations with biological entities spanning 2 categories (cell line, cell type or tissue, gene, protein or microRNA) extracted from 6 datasets.

Click the + buttons to view associations for MIR5196 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5196 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5196 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR5196 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR5196 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR5196 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR5196 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.