MIR519A2 Gene

HGNC Family Non-coding RNAs
Name microRNA 519a-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA-519 (MIR519A2) plays a key regulatory role in post‐transcriptional gene expression by directly repressing the translation of HuR, an RNA‐binding protein that stabilizes mRNAs involved in cell proliferation. Binding preferentially to HuR’s coding region and, to a lesser extent, its 3′-UTR, miR-519 limits HuR protein synthesis without altering HuR mRNA levels and thereby decreases cell proliferation. This mechanism supports its function as a suppressor of oncogenic pathways by indirectly modulating the expression of HuR target genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "MicroRNA-519 has also been implicated in the clinical landscape of human cancers. Aberrant miR-519 expression in ovarian tumors suggests its potential utility as a diagnostic and prognostic biomarker, while other studies have reported its tumor suppressor activity in esophageal squamous cell carcinoma, underscoring its relevance in malignancy-associated signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Beyond its role in tumor biology, miR-519 expression is also observed in placental tissues, with differential levels noted in pathological conditions such as preeclampsia. Elevated miR-519a in the syncytiotrophoblast and specific placental villi correlates with trophoblast damage and altered gene expression—findings that may reflect compensatory mechanisms involving invasion and oncoprotection in the context of gestational complications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kotb Abdelmohsen, Subramanya Srikantan, Yuki Kuwano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0809376106"}], "href": "https://doi.org/10.1073/pnas.0809376106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19088191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19088191"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tae Heon Kim, Yu Kyung Kim, Youngdo Kwon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2559.2010.03686.x"}], "href": "https://doi.org/10.1111/j.1365-2559.2010.03686.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21083603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21083603"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanshan Zhang, Weizuo Chen, Huijuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-519 enhances radiosensitivity of esophageal squamous cell carcinoma trough targeting PI3K/AKT/mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Chemother Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00280-019-03922-2"}], "href": "https://doi.org/10.1007/s00280-019-03922-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31529206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31529206"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "N V Nizyaeva, G V Kulikova, M N Nagovitsyna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Change in OncomicroRNA Expression in the Placenta during Preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-018-4267-7"}], "href": "https://doi.org/10.1007/s10517-018-4267-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30353329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30353329"}]}]}]}
Synonyms MIRN519A-2, MIRN519A2, MIR-519A-2
NCBI Gene ID 574500
API
Download Associations
Predicted Functions View MIR519A2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR519A2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR519A2's ARCHS4 Predicted Functions.

Functional Associations

MIR519A2 has 196 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR519A2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR519A2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR519A2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR519A2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR519A2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR519A2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR519A2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR519A2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR519A2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR519A2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR519A2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR519A2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR519A2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.