{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe miR‐519 family, particularly miR‐519B (and its variant miR‐519b‑3p), has emerged as a pivotal regulator of mRNA translation in diverse cancer contexts. In human carcinoma cells, miR‐519 directly binds to two sites on the HuR mRNA—one within the coding region and one in the 3′‑UTR—to suppress its translation without altering mRNA levels. This repression of HuR, a critical RNA‑binding protein that stabilizes and modulates the translation of many proliferation‐promoting transcripts, ultimately leads to reduced cell division and altered expression of HuR‑regulated genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, miR‐519B binds specifically to the 3′‑UTR of the full‑length NK1 receptor mRNA (NK1‑FL) and decreases its translation, thereby shifting the balance toward the oncogenic truncated isoform (NK1‑Tr). This selective regulation highlights its potential to influence receptor isoform expression and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In rectal cancer, elevated miR‐519b‑3p expression correlates with an enhanced response to preoperative chemoradiotherapy by directly targeting ARID4B mRNA, suggesting its promise as a predictive biomarker for treatment efficacy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, studies in esophageal squamous cell carcinoma support a tumor‐suppressive role for miR‐519."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In lung adenocarcinoma, the oncogenic lncRNA LINC01419 exerts its tumor‑promoting effects by sponging miR‐519b‑3p, which normally suppresses RCCD1 expression, thereby reinforcing the multifaceted roles of miR‐519B in modulating key oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kotb Abdelmohsen, Subramanya Srikantan, Yuki Kuwano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0809376106"}], "href": "https://doi.org/10.1073/pnas.0809376106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19088191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19088191"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peter Navarro, Shakti H Ramkissoon, Simant Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2012.09.002"}], "href": "https://doi.org/10.1016/j.yexcr.2012.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22981979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22981979"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jialin Luo, Luying Liu, Ning Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-519b-3p promotes responsiveness to preoperative chemoradiotherapy in rectal cancer patients by targeting ARID4B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.02.056"}], "href": "https://doi.org/10.1016/j.gene.2018.02.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29477868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29477868"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanshan Zhang, Weizuo Chen, Huijuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-519 enhances radiosensitivity of esophageal squamous cell carcinoma trough targeting PI3K/AKT/mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Chemother Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00280-019-03922-2"}], "href": "https://doi.org/10.1007/s00280-019-03922-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31529206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31529206"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ziming Cheng, Shizhen Hou, Yubing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01419 promotes cell proliferation and metastasis in lung adenocarcinoma via sponging miR-519b-3p to up-regulate RCCD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.09.090"}], "href": "https://doi.org/10.1016/j.bbrc.2019.09.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31582214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31582214"}]}]}]}