MIR520E Gene

HGNC Family Non-coding RNAs
Name microRNA 520e
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐520e (miR-520e) emerges as a critical regulatory molecule with tumor‐suppressive functions in various human cancers. In hepatocellular carcinoma, miR-520e is markedly downregulated—often via upstream DNA hypermethylation—thereby releasing its direct target, NF-κB-inducing kinase (NIK), which in turn activates downstream signaling (e.g., p-ERK1/2/NF-κB) that promotes hepatoma cell proliferation. These findings underscore miR-520e’s role in curbing tumor growth through inhibition of oncogenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its function in liver cancer, miR-520e has been implicated in other pathological states. In visceral adipose tissue, it partners with the regulation of RAB11A—an important effector in glucose homeostasis and lipid metabolism—suggesting that miR-520e may contribute to metabolic disturbances in obesity. In gastric cancer, it is identified as part of the miR-520b/e group displaying tumor-suppressive activity, potentially linked to modulation of epidermal growth factor receptor (EGFR) signaling. Furthermore, in non-small-cell lung cancer (NSCLC), miR-520e suppresses malignant progression by targeting the transcription factor Zbtb7a and influencing Wnt signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nmiR-520e also plays a notable role in virus-associated and other cancers. In hepatitis B virus (HBV)-positive hepatocellular carcinoma, miR-520e modulates EphA2 expression and, by extension, disrupts p38MAPK/ERK1/2 signaling to simultaneously reduce viral replication and tumor growth. In gliomas, overexpression of miR-520e restricts cell proliferation and invasion by downregulating FGF19 and subsequent Wnt/β-catenin signaling. Finally, in osteosarcoma, the regulatory interplay between long noncoding RNA ZFAS1 and miR-520e affects RHOC expression, thereby influencing tumor progression. These studies collectively highlight the multifaceted role of miR-520e as a tumor suppressor and a potential therapeutic target in diverse pathological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Zhang, C Shan, G Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.523"}], "href": "https://doi.org/10.1038/onc.2011.523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22105365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22105365"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Valentina Capobianco, Carmela Nardelli, Maddalena Ferrigno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr300152z"}], "href": "https://doi.org/10.1021/pr300152z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22537031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22537031"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shuang Li, Haiyang Zhang, Tao Ning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-520b/e Regulates Proliferation and Migration by Simultaneously Targeting EGFR in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000453183"}], "href": "https://doi.org/10.1159/000453183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27997901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27997901"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhu Zhijun, He Jingkang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-520e suppresses non-small-cell lung cancer cell growth by targeting Zbtb7a-mediated Wnt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.02.121"}], "href": "https://doi.org/10.1016/j.bbrc.2017.02.121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28242196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28242196"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing-Hui Tian, Wen-Dong Liu, Zhi-Yong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of miR-520e-mediated MAPK signalling pathway on HBV replication and regulation of hepatocellular carcinoma cells via targeting EphA2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Viral Hepat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jvh.13048"}], "href": "https://doi.org/10.1111/jvh.13048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30521133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30521133"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Liang Zhang, Yidong Cao, Dong Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-520e restricts the proliferation and invasion of glioma cells through the downregulation of Wnt/β-catenin signaling by targeting fibroblast growth factor 19."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.02.112"}], "href": "https://doi.org/10.1016/j.bbrc.2019.02.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30826062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30826062"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaofeng Liu, Mingyang Wang, Liwen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clinics (Sao Paulo) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinsp.2022.100143"}], "href": "https://doi.org/10.1016/j.clinsp.2022.100143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36473367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36473367"}]}]}]}
Synonyms MIRN520E
NCBI Gene ID 574461
API
Download Associations
Predicted Functions View MIR520E's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR520E's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR520E's ARCHS4 Predicted Functions.

Functional Associations

MIR520E has 205 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR520E from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR520E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR520E gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR520E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR520E gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR520E gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR520E gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR520E gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR520E gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR520E from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR520E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR520E gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR520E gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.