MIR520G Gene

HGNC Family Non-coding RNAs
Name microRNA 520g
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑520g, a member of the miR‑520 family, has emerged as an important regulator of oncogenic processes across multiple tumor types. In primary central nervous system primitive neuroectodermal tumors (CNS‑PNET), high‐level amplification of the C19MC cluster leads to robust overexpression of miR‑520g. Its constitutive expression in untransformed human neural stem cells enhances oncogenicity by promoting cell survival, stimulating growth through upregulation of WNT signaling, and restricting differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, increased miR‑520g expression has been correlated with resistance to chemotherapeutic agents such as 5‑fluorouracil and oxaliplatin. Experimental data indicate that ectopic expression of miR‑520g confers resistance to apoptosis by downregulating the cyclin-dependent kinase inhibitor p21, while p53 acts as a negative regulator of miR‑520g expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, circulating levels of miR‑520g detected in peripheral blood samples have been evaluated as a potential biomarker. Its altered expression suggests an association with disease progression and highlights its promise in early diagnosis and prognosis in patients with this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in epithelial ovarian cancer, increased miR‑520g expression is associated with advanced tumor progression, enhanced chemoresistance to platinum‐based therapies, and diminished patient survival. Mechanistically, miR‑520g mediates its oncogenic and drug resistance effects by post‑transcriptionally downregulating death‑associated protein kinase 2 (DAPK2), suggesting that targeting the miR‑520g/DAPK2 axis could offer therapeutic benefit."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, recent studies have revealed that circular RNAs (circRNAs) such as circ_0102049 act as molecular sponges for miR‑520g‑3p. In this context, sequestration of miR‑520g relieves its inhibition on polo‑like kinase 2 (PLK2), thereby suppressing osteosarcoma cell proliferation, invasion, and migration while promoting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in colorectal cancer, another circRNA (circ_0000317) suppresses malignant phenotypes by targeting miR‑520g, which in turn modulates the expression of homeobox D10 (HOXD10). This regulatory axis contributes to decreased cell proliferation, migration, and invasion, further underscoring the multifaceted role of miR‑520g in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meihua Li, Kyle F Lee, Yuntao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2009.10.025"}], "href": "https://doi.org/10.1016/j.ccr.2009.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19962671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19962671"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Zhang, Liying Geng, Geoffrey Talmon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-520g confers drug resistance by regulating p21 expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.620252"}], "href": "https://doi.org/10.1074/jbc.M114.620252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25616665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25616665"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "G-B Ren, L Wang, F-H Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Study on the relationship between miR-520g and the development of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26957267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26957267"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Zhang, Lei Liu, Yunyan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8530"}], "href": "https://doi.org/10.18632/oncotarget.8530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27049921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27049921"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xianliao Zhang, Zhengbo Hu, Wenhu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1923259"}], "href": "https://doi.org/10.1080/21655979.2021.1923259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34060415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34060415"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fu-Ji Lai, Hua Yu, Yang-Yang Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0000317/microRNA-520g/HOXD10 axis affects the biological characteristics of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12422"}], "href": "https://doi.org/10.1002/kjm2.12422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34292663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34292663"}]}]}]}
Synonyms MIR-520G, MIRN520G
NCBI Gene ID 574484
API
Download Associations
Predicted Functions View MIR520G's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR520G's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR520G's ARCHS4 Predicted Functions.

Functional Associations

MIR520G has 217 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR520G from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR520G gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR520G gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR520G gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR520G gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR520G gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR520G gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR520G gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR520G gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR520G from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR520G gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR520G gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR520G gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.