MIR522 Gene

HGNC Family Non-coding RNAs
Name microRNA 522
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In poorly differentiated cancers, miR‑522 has been shown to affect cell proliferation, cell cycle progression, detachment, migration, invasion, and epithelial–mesenchymal transition by targeting a broad range of transcripts via noncanonical microRNA recognition elements (for example, see studies reporting its oncogenic effects and unconventional targeting mechanisms)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Genetic variation can modulate its function, as illustrated by a single nucleotide polymorphism in the 3′UTR of PLIN4 that creates a binding site for miR‑522, thereby altering obesity‑related phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of cancer drug resistance, miR‑522 is downregulated in doxorubicin‑resistant colon cancer cells, and its overexpression restores sensitivity by targeting the drug transporter ABCB5."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, elevated miR‑522 levels promote hepatocellular carcinoma progression by accelerating the G1/S cell cycle transition—via downregulation of cell cycle inhibitors and activation of Wnt signaling through targeting antagonists such as DKK1 and SFRP2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "—and enhance glioblastoma cell proliferation by suppressing the tumor‑suppressive phosphatase PHLPP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In inflammatory settings, miR‑522 contributes to pathological processes by upregulating proinflammatory cytokines and matrix metalloproteinases through inhibition of SOCS3 in rheumatoid arthritis synovial fibroblasts"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and by participating in an HMGB1–miR‑522–PTGR1 axis that may impair the resolution of inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In breast cancer, high miR‑522 expression is associated with lymph node metastasis and poor overall survival; here, miR‑522 promotes malignant progression by targeting key tumor suppressors including BRCA1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and ΔNp63α, the latter leading to enhanced migratory behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, binding site variations affecting miR‑522 interaction with PBX1 further underscore its involvement in tumor metastasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and its activity is modulated by long non‑coding RNAs such as DHRS4‑AS1 in hepatocellular carcinoma, which sequester miR‑522 and thereby influence downstream effectors like SOCS5."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "11"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shen Mynn Tan, Rory Kirchner, Jingmin Jin, et al. 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Synonyms HSA-MIR-522, MIR-522, MIRN522
NCBI Gene ID 574495
API
Download Associations
Predicted Functions View MIR522's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR522's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR522's ARCHS4 Predicted Functions.

Functional Associations

MIR522 has 195 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR522 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR522 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR522 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR522 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR522 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR522 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR522 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR522 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR522 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR522 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR522 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.