MIR523 Gene

HGNC Family Non-coding RNAs
Name microRNA 523
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the complex roles of different MIR523 isoforms as regulators in diverse disease settings. In a study on rheumatoid arthritis (RA), the lncRNA ZNF667‐AS1 was investigated for its impact on RA progression, although a direct connection to MIR523 was not explored in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn retinoblastoma, MIR523 in its –3p form has been implicated as an oncogenic microRNA. Here, the tumor‐suppressive lncRNA Linc‐PINT was shown to inhibit tumor development by sponging miR‐523-3p, thereby relieving its suppression on Dickkopf-1 (DKK1). Functional experiments demonstrated that elevated miR‐523-3p levels support malignant phenotypes—including enhanced cell growth, invasion, and migration—while its downregulation promoted apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in laryngeal squamous cell carcinoma, an isoform designated as miR‐523-5p is sequestered by the oncogenic lncRNA LINC01638. This interaction leads to increased expression of BATF3, a factor that contributes to tumor progression. In colon cancer, elevated miR‐523-3p levels promote oncogenesis by targeting both ZNF667-AS1 and the 3’ untranslated region of KIF5C, thereby reducing the levels of this tumor-suppressor. Restoration of ZNF667-AS1 expression counteracted the miR‐523-3p–mediated inhibition of KIF5C, ultimately suppressing colon cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qin Zhuo, Lu Wei, Xietian Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZNF667-AS1 alleviates rheumatoid arthritis by sponging miR-523-3p and inactivating the JAK/STAT signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autoimmunity (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/08916934.2021.1966770"}], "href": "https://doi.org/10.1080/08916934.2021.1966770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34423698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34423698"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoping Zhou, Yongping Wang, Qiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA Linc-PINT inhibits miR-523-3p to hamper retinoblastoma progression by upregulating Dickkopf-1 (DKK1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.06.120"}], "href": "https://doi.org/10.1016/j.bbrc.2020.06.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32828314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32828314"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hang Zhang, Xudong Zhao, Mengmeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202675"}], "href": "https://doi.org/10.18632/aging.202675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33714208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33714208"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Duan Tong, Lili Fan "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-023-00772-5"}], "href": "https://doi.org/10.1007/s12033-023-00772-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37322260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37322260"}]}]}]}
Synonyms HSA-MIR-523, MIR-523, MIRN523
NCBI Gene ID 574471
API
Download Associations
Predicted Functions View MIR523's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR523's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR523's ARCHS4 Predicted Functions.

Functional Associations

MIR523 has 177 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR523 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR523 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR523 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR523 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR523 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR523 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR523 from the GeneSigDB Published Gene Signatures dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR523 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR523 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR523 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.