MIR525 Gene

HGNC Family Non-coding RNAs
Name microRNA 525
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies across multiple cancer types have revealed divergent roles for distinct MIR525 isoforms. For instance, in liver cancer, miR‐525‐3p is frequently up‐regulated and promotes cell migration and invasion by directly targeting the metastasis‐suppressor ZNF395."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, circFAT1 confers oxaliplatin resistance by sponging miR‐525‐5p, which in turn leads to increased SKA1 expression and subsequent activation of the Notch and Wnt pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, dysregulated androgen receptor signaling in prostate and bladder cancers differentially alters miR‐525‐5p levels, thereby modulating the expression of the vasculogenic mimicry marker SLPI and impacting metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, sponging of miR‐525‐3p by circRNA_0074027 impedes its tumor‐suppressive functions—such as p53 upregulation and epithelial–mesenchymal transition inhibition—thus contributing to cancer progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in diffuse large B‐cell lymphoma, reduced levels of miR‐525‐5p relieve inhibition of Myd88/NF‐κB signaling, thereby enhancing tumor cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIR525 isoforms also play key roles in immune modulation and host–pathogen interactions. In pediatric systemic lupus erythematosus, elevated miR‐525‐5p expression is associated with active disease and correlates with increased C‐reactive protein levels, suggesting its utility as a potential biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, miR‐525‐5p regulates immune receptor expression by targeting the 3′ untranslated region of VPAC‐1, thereby influencing pathways implicated in both immune‐mediated and neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " During rotavirus infection, miR‐525‐3p exerts an antiviral effect by binding to the 3′ UTR of the viral NSP1 gene and promoting type I interferon as well as proinflammatory cytokine responses, ultimately suppressing viral replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer and infection, MIR525 isoforms influence cell invasion and tissue inflammation in other pathological contexts. In trophoblast cells, miR‐525‐5p modulates invasive capacity; mechanistic studies indicate that its regulation—via interaction with circular RNAs—alters ABL1 expression, thereby impacting migration and invasion processes that are critical in the pathogenesis of preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Similarly, in diabetic nephropathy, high-glucose conditions lead to downregulation of miR‐525‐5p via upregulation of lncRNA ZFAS1, which in turn causes increased SGK1 expression and promotes renal fibrosis and inflammation; restoration of miR‐525‐5p levels appears to offer renal protection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fei Pang, Ruopeng Zha, Yingjun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0090867"}], "href": "https://doi.org/10.1371/journal.pone.0090867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24599008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24599008"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ye Yao, Xiaoqin Li, Lihua Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1951929"}], "href": "https://doi.org/10.1080/21655979.2021.1951929"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34288822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34288822"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhao Yang, Jiaqi Chen, Hongjun Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.12.018"}], "href": "https://doi.org/10.1016/j.canlet.2019.12.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31843555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31843555"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gang Xiong, Jun Zhang, Yichao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA_0074027 participates in cell proliferation, apoptosis and metastasis of colorectal cancer cells through regulation of miR‑525‑3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.11963"}], "href": "https://doi.org/10.3892/mmr.2021.11963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33760126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33760126"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiuchen Guo, Jingbo Zhang, Jingya Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-525-5p inhibits diffuse large B cell lymphoma progression via the Myd88/NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.16388"}], "href": "https://doi.org/10.7717/peerj.16388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37953776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37953776"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jia Zhu, Xiaolan Huang, Gaixiu Su, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Single nucleotide polymorphisms in the 3'UTR of VPAC-1 cooperate in modulating gene expression and impact differently on the interaction with miR525-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0112646"}], "href": "https://doi.org/10.1371/journal.pone.0112646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25390694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25390694"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhiqiang Tian, Ji Zhang, Haiyang He, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Biochem Biotechnol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12010-023-04721-5"}], "href": "https://doi.org/10.1007/s12010-023-04721-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37768477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37768477"}]}]}]}
Synonyms MIRN525, HSA-MIR-525
NCBI Gene ID 574470
API
Download Associations
Predicted Functions View MIR525's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR525's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR525's ARCHS4 Predicted Functions.

Functional Associations

MIR525 has 220 functional associations with biological entities spanning 5 categories (molecular profile, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR525 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR525 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR525 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with MIR525 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR525 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR525 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR525 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR525 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR525 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR525 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR525 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR525 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR525 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.