MIR527 Gene

HGNC Family Non-coding RNAs
Name microRNA 527
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In one study, the long noncoding RNA MNX1‑AS1 was found to be highly upregulated in lung cancer tissues and to promote proliferation, migration, and invasion by sequestering miR-527, thereby releasing its inhibitory effect on BRF2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, miR-527 directly targets SULF2 to regulate the TGF‑β/SMAD signaling pathway that induces epithelial–mesenchymal transition (EMT) in non‑small‑cell lung cancer, reinforcing its role as a counterbalance against oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of metastasis, altered miR‑527 expression has also been implicated in facilitating tumor dissemination. In human osteosarcoma models, the ΔNp63α isoform repressed miR‑527 (along with miR‑665) in a TGF‑β–rich environment; this repression led to the upregulation of key TGF‑β effectors, including SMAD4 and TGFBR2, which in turn promoted metastatic spread and underscored a role for miR‑527 in maintaining the balance during wound-healing responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA series of studies have revealed that various circular RNAs and other noncoding RNAs contribute to disease progression by sponging miR‑527, thereby neutralizing its tumor‑suppressive activities. For example, in lung cancer stem cells, circ_0003222 sequesters miR‑527, leading to increased PHF21B/β-catenin signaling and enhanced cell stemness and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in gastric cancer, circ_0005529 interacts with miR‑527 to elevate Sp1 expression and promote cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In periodontitis, the circRNA circ_0138959 sponges miR‑527, which normally targets CASP5 to regulate pyroptosis in human gingival fibroblasts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " This sponging mechanism is also observed in bladder cancer, where circ_0001495 inhibits miR‑527 to upregulate Robo1, thereby driving cancer cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, reduced miR‑527 levels in plasma and tissue samples from prostate cancer patients further support its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haibo Liu, Leng Han, Zhengjia Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA MNX1-AS1 contributes to lung cancer progression through the miR-527/BRF2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28064"}], "href": "https://doi.org/10.1002/jcp.28064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30618167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30618167"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Huo, Xiao-Min Zhu, Xin-Yan Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Math Biosci Eng (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3934/mbe.2019231"}], "href": "https://doi.org/10.3934/mbe.2019231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31499680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31499680"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lidia Rodriguez Calleja, Camille Jacques, François Lamoureux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2317"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26988989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26988989"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Changhui Li, Jiaqi Zhang, Xiaohua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04095-8"}], "href": "https://doi.org/10.1038/s41419-021-04095-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34433810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34433810"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xing Zhang, Hongwei Yang, Yingdong Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12860-020-00340-8"}], "href": "https://doi.org/10.1186/s12860-020-00340-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33472586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33472586"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jiaxin Pan, Lu Zhao, Jue Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2020396"}], "href": "https://doi.org/10.1080/21655979.2021.2020396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35030963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35030963"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Liuwei Feng, Dongmei Fu, Lei Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA_0001495 increases Robo1 expression by sponging microRNA-527 to promote the proliferation, migration and invasion of bladder cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgab040"}], "href": "https://doi.org/10.1093/carcin/bgab040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34021307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34021307"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mohd Mabood Khan, Mohammad Serajuddin, Mausumi Bharadwaj "}, {"type": "b", "children": [{"type": "t", "text": "Potential plasma microRNAs signature miR-190b-5p, miR-215-5p and miR-527 as non-invasive biomarkers for prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/1354750X.2022.2163694"}], "href": "https://doi.org/10.1080/1354750X.2022.2163694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36644827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36644827"}]}]}]}
Synonyms MIRN527, HSA-MIR-527
NCBI Gene ID 574497
API
Download Associations
Predicted Functions View MIR527's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR527's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR527's ARCHS4 Predicted Functions.

Functional Associations

MIR527 has 169 functional associations with biological entities spanning 5 categories (molecular profile, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR527 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR527 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR527 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with MIR527 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR527 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR527 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR527 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR527 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR527 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR527 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.