MIR541 Gene

HGNC Family Non-coding RNAs
Name microRNA 541
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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On one hand, the long non‐coding RNA LOXL1‑AS1, which is primarily cytoplasmic, interacts with miR‑541‑3p to control the expression of the cell cycle regulator CCND1; its suppression leads to reduced cell proliferation and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " On the other, infiltrating CD4(+) T cells have been shown to modulate a pathway involving FGF11 and miR‑541, resulting in the suppression of androgen receptor signaling and downstream MMP9 expression, thereby facilitating prostate cancer invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer, miR‑541 functions as a tumor‐suppressive microRNA. In non‐small cell lung cancer (NSCLC), reduced levels of miR‑541‑3p correlate with advanced tumor stage and poor survival, whereas its restoration significantly impedes cell growth and metastasis by directly targeting TGIF2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in squamous cell lung carcinoma, overexpression of miR‑541 directly targets HMGA2 to inhibit tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in oncogenesis and differentiation, miR‑541 has been implicated in other biomedical contexts. For instance, analysis of vitreous humor miRNA signatures revealed that miR‑541 levels vary in a day–night pattern, suggesting its potential as a forensic biomarker for estimating the time of death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Additionally, in models of acute lung injury, the miR‑541‑5p isoform is markedly reduced; its overexpression enhances alveolar type II cell viability and proliferation by modulating HMGB1 expression and associated JNK/ERK/p38 signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPreliminary investigations also suggest a broader involvement of miR‑541 in other pathological conditions. Studies in hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and in liver cirrhosis, as well as emerging roles in gastric cancer cell–macrophage communication"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and fibrotic diseases"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", underscore its versatile functions as a tumor suppressor and regulator of cellular homeostasis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takanori Eguchi, Ken Watanabe, Emilio Satoshi Hara, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.09.160"}], "href": "https://doi.org/10.1016/j.bbrc.2018.09.160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30278884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30278884"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shuai Hu, Lei Li, Shuyuan Yeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2014.07.013"}], "href": "https://doi.org/10.1016/j.molonc.2014.07.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25135278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25135278"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "You-Jin Lu, Rong-Yu Liu, Kun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5241-5"}], "href": "https://doi.org/10.1007/s13277-016-5241-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27448300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27448300"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li Xu, Bin Du, Qi-Jue Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-541 suppresses proliferation and invasion of squamous cell lung carcinoma cell lines via directly targeting high-mobility group AT-hook 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1491"}], "href": "https://doi.org/10.1002/cam4.1491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29659195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29659195"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Adrián Odriozola, José A Riancho, Rosa de la Vega, et al. 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Synonyms HSA-MIR-541, MIRN541, MIR-541
NCBI Gene ID 100126308
API
Download Associations
Predicted Functions View MIR541's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR541's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR541's ARCHS4 Predicted Functions.

Functional Associations

MIR541 has 301 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR541 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR541 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR541 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR541 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR541 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR541 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR541 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR541 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR541 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR541 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR541 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR541 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR541 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.